A5047605621- Cancer, Lipids, and Metabolism
- Cardiovascular Syncope and Autonomic Disorders
- Glutathione Transferases and Polymorphisms
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Cardiac Arrest and Resuscitation
Cangzhou Central Hospital
2024-2025
Cisplatin (DDP) resistance remains a primary cause of chemotherapy failure and recurrence non-small cell lung cancer (NSCLC). Abnormal high microsomal glutathione transferase 1 (MGST1) expression has been found in DDP-resistant NSCLC cells. This study aimed to explore the function mechanism MGST1 DDP The levels target molecules were assessed by quantitative real-time polymerase chain reaction (RT-qPCR) western blotting. Cell proliferation was evaluated counting kit-8 (CCK-8) colony formation...
Objective: To investigate the effect of esmolol in septic shock patients with tachycardia. Methods: A prospective randomized controlled trial was conducted. Screening that admitted to Department General Intensive Care Unit First Affiliated Hospital Zhengzhou University from June 2016 August 2017. After 24 h resuscitation therapy, 100 cases tachycardia (heart rate>100 bpm) were divided into group (n=50) and control random number table. Patients accepted standard treatment plus injection an...
Non-small-cell lung cancer (NSCLC) remains a deadly malignancy worldwide. Resistance to cisplatin (DDP) is significant obstacle that limits the therapeutic efficacy in NSCLC patients. This study investigated role and mechanism of 24-dehydrocholesterol reductase (DHCR24) DDP resistance cells. levels, ferroptosis-related molecules, proteins involved PI3K/AKT/GSK3β pathway were measured. The growth capacity cells was evaluated, ferroptosis assessed by measuring MDA, GSH, Fe2+, ROS levels....