A5058236221- BRCA gene mutations in cancer
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer Risks and Factors
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
- Vestibular and auditory disorders
- Sexual Differentiation and Disorders
- Vitamin C and Antioxidants Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Effects of Radiation Exposure
- Ear Surgery and Otitis Media
- Bladder and Urothelial Cancer Treatments
- Ubiquitin and proteasome pathways
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Chemotherapy-induced cardiotoxicity and mitigation
Umm al-Qura University
2022-2025
King Abdulaziz University
2023
University of Jeddah
2023
Université de Montpellier
2017
Abstract Hearing loss is the most common sensory disorder and because of its high genetic heterogeneity, implementation Massively Parallel Sequencing (MPS) in diagnostic laboratories greatly improving possibilities offering optimal care to patients. We present results a two-year period molecular diagnosis that included 207 French families referred for non-syndromic hearing loss. Our multi-step strategy involved (i) DFNB1 locus analysis, (ii) MPS 74 genes, (iii) additional approaches...
Background and Objectives: 5-Fluorouracil (5-FU) is a widely prescribed effective chemotherapeutic drug, but its cardiotoxic side effects pose significant challenge to use. Identifying protective agent that does not affect anticancer efficacy essential. Our study aimed investigate the cardioprotective effect of N-acetyl cysteine (NAC) against 5-FU-induced cardiac injury elucidate underlying mechanisms. Materials Methods: This included four experimental groups, each with eight rats (n = 8):...
This review provides descriptive evidence for the potential sociodemographic risk factors of race/ethnicity, younger age, and socioeconomic status, as well immigrant effect in women with breast cancer (BC) across world regions countries. Using MEDLINE Web Science on epidemiology, incidence/mortality rates, social determinants, we searched a registry-based dataset reference lists prior reviews BC (code C50) from GLOBOCAN 2022 database National Cancer Institute's Surveillance, Epidemiology,...
The
Translocation of sex/autosome chromosomes is uncommon, but they have a stronger impact on fertility than autosome/autosome translocation. Y/autosome translocation associated with azoospermia in 80% cases. To our knowledge, there been only eight cases reported balanced reciprocal (Y;16) male infertility.Here we report an infertile man who has t(Y;16) (q12; p13.2). A 38-year-old Saudi medically free presented primary infertility and for six years. He positive family history infertility....