A5100850678- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Reconstructive Surgery and Microvascular Techniques
- Developmental Biology and Gene Regulation
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Veterinary Oncology Research
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Circular RNAs in diseases
- RNA modifications and cancer
- Sarcoma Diagnosis and Treatment
- Infectious Diseases and Mycology
- Inflammatory mediators and NSAID effects
Southwest Minzu University
2024-2025
Texas Tech University
2025
The University of Texas MD Anderson Cancer Center
2011-2024
Zhongshan Hospital
2008-2024
Fudan University
2014-2024
Clinical Trial Investigators
2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2020
Sun Yat-sen University
2015-2020
Shanghai Children's Medical Center
2010-2012
Abstract Purpose: Notch signaling is an important mediator of growth and survival in several cancer types, with pathway genes functioning as oncogenes or tumor suppressors different cancers. However, the role osteosarcoma unknown. Experimental Design: We assessed expression human cell lines patient samples. then used pharmacologic retroviral manipulation studied effect on proliferation, survival, anchorage-independent growth, invasion, metastasis vitro vivo. Results: genes, including ligand...
Circular RNAs (circRNAs) have been reported to critical regulatory roles in tumor biology. However, their contribution melanoma remains largely unknown.CircRNAs derived from oncogene CD151 were detected and verified by analyzing a large number of samples through quantitative real-time polymerase chain reaction (qRT-PCR). Melanoma cells stably transfected with lentiviruses using circ_0020710 interference or overexpression plasmid, then CCK-8, colony formation, wound healing, transwell...
Ring finger proteins (RNFs) were involved in carcinogenesis. Here, we aimed to explore the detailed mechanism of RNF128 progression melanoma. We reanalyzed several gene expression profiles from Gene Expression Omnibus (GEO) database and obtained overlapped differential expressed RNF genes. Among them, was selected further its expression, biological significance, underlying molecular mechanism, as well clinical relevance melanoma patients. found be significantly downregulated datasets, which...
Abstract Radiotherapy (RT) can induce tumor regression outside the irradiation field, known as abscopal effect. However, detailed underlying mechanisms remain largely unknown. A tumor‐bearing mouse model is successfully constructed by inducing both subcutaneous tumors and lung metastases. Single‐cell RNA sequencing, immunofluorescence, flow cytometry are performed to explore regulation of microenvironment (TME) RT. series in vitro assays, including luciferase reporter, Pulldown, fluorescent...
Diffuse midline gliomas (DMG), including brainstem diffuse intrinsic pontine glioma (DIPG), are incurable pediatric high-grade (pHGG). Mutations in the H3 histone tail (H3.1/3.3-K27M) a feature of DIPG, rendering them therapeutically sensitive to small-molecule inhibition chromatin modifiers. Pharmacological lysine-specific demethylase 1 (LSD1) is clinically relevant but has not been carefully investigated pHGG or DIPG.Patient-derived DIPG cell lines, orthotopic mouse models, and datasets...
Abstract Background Cell proliferation and death are key components of wound healing tissue repair. Telocytes (TCs) represent a newly discovered cell type that can protect from acute injury via cell–cell communication with adjacent cells. The aim this study was to use mouse model skin lipopolysaccharide (LPS)-induced evaluate the effects TCs on in vivo vitro. Material/methods Immunohistochemical staining performed alteration tissues normal chronic patients. Then, male C57BL/6 back...
Abstract Acral melanoma (AM) is a rare subtype of characterized by high incidence lymph node (LN) metastasis, critical factor in tumor dissemination and therapeutic decision-making. Here, we employ single-cell spatial transcriptomic analyses to investigate the dynamic evolution early AM dissemination. Our findings reveal substantial inter- intra-tumor heterogeneity AM, alongside highly immunosuppressive microenvironment complex intercellular communication networks, particularly patients with...
Abstract Huanglian Jiedu decoction (HLJD) has been used to treat ischemic stroke in clinic. However, the detailed protective mechanisms of HLJD on have yet be elucidated. The aim this study is elucidate underlying pharmacological based inhibition neuroinflammation and amelioration nerve cell damage. A middle cerebral artery occlusion reperfusion (MCAO/R) model was established rats received treatment. Effects neurological function assessed Bederson's score, postural reflex test asymmetry...
Canines spontaneously develop many cancers similar to humans - including osteosarcoma, leukemia, and lymphoma offering the opportunity study immune therapies in a genetically heterogeneous immunocompetent environment. However, lack of antibodies recognizing canine NK cell markers has resulted suboptimal characterization unknown purity products, hindering development models adoptive immunotherapy. To this end, we generated novel antibody NCR1 (NKp46), putative species-wide marker cells,...
Abstract Background Melanoma is the deadliest form of skin tumor, and G protein-coupled receptors (GPCRs) play crucial roles in its carcinogenesis. Furthermore, tumor microenvironment (TME) affects overall survival (OS) response to immunotherapy. The combination GPCRs TME from a multi-omics perspective may help predict melanoma patients their Methods Bulk-seq, single-cell RNA sequencing (scRNA-seq), gene mutations, immunotherapy responses, clinicopathologic feature data were downloaded...
Vascular dementia is the second most common type of and a preventable disease, but its complex etiology difficult diagnosis make it occupy high status in field neuroscience geriatrics. At present, modern medicine mainly takes oral donepezil other drugs to control vascular risk factors improve cognitive function (non-) drugs; summarizes epidemiology, related factors, pathogenesis, treatment plan future direction dementia.
Abstract Metabolic reprogramming promotes and sustains multiple steps of melanoma metastasis. Identification key regulators metabolic could lead to the development treatments for preventing treating metastatic melanoma. Here, we identified that tectonic family member TCTN1 metastasis by increasing fatty acid oxidation (FAO). In clinical samples, high expression correlated with increased shorter patient survival. Functionally, promoted invasion migration in vitro distant vivo, induced a...
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<div>Abstract<p>Metabolic reprogramming promotes and sustains multiple steps of melanoma metastasis. Identification key regulators metabolic could lead to the development treatments for preventing treating metastatic melanoma. In this study, we identified that tectonic family member 1 (TCTN1) metastasis by increasing fatty acid oxidation (FAO). clinical samples, high expression TCTN1 correlated with increased shorter patient survival. Functionally, promoted invasion migration...
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