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Yaxin Chen

ORCID: 0009-0004-3403-3465
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A5006244638
Research Areas
  • Cancer, Stress, Anesthesia, and Immune Response
  • Advanced Breast Cancer Therapies
  • Cancer Cells and Metastasis
  • Receptor Mechanisms and Signaling
  • Circular RNAs in diseases
  • Mycobacterium research and diagnosis
  • Cancer-related molecular mechanisms research

China Pharmaceutical University
 2024

 Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired migration cell, well...

10.1158/1541-7786.mcr-23-0513 article EN Molecular Cancer Research 2024-02-21
 Data from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<div>Abstract<p>A number of neurotransmitters have been detected in tumor microenvironment and proved to modulate cancer oncogenesis progression. We previously found that biosynthesis secretion neurotransmitter 5-hydroxytryptamine (5-HT) was elevated colorectal cells. In this study, we discovered the HTR2B receptor 5-HT highly expressed tissues, which further identified as a strong risk factor for prognostic outcomes. Both pharmacological blocking genetic knocking down impaired...

10.1158/1541-7786.c.7267998 preprint EN 2024-06-04
 Supplementary Figure S11 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S11 and its legend.</p>

10.1158/1541-7786.25964919 preprint EN cc-by 2024-06-04
 Supplementary Figure S14 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S14 and its legend.</p>

10.1158/1541-7786.25964907.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S9 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S9 and its legend.</p>

10.1158/1541-7786.25964862.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S4 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S4 and its legend.</p>

10.1158/1541-7786.25964877.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S13 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S13 and its legend.</p>

10.1158/1541-7786.25964910.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S20 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S20 and its legend.</p>

10.1158/1541-7786.25964883.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S10 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S10 and its legend.</p>

10.1158/1541-7786.25964922.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S1 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S1 and its legend.</p>

10.1158/1541-7786.25964925 preprint EN cc-by 2024-06-04
 Supplementary Figure S18 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S18 and its legend.</p>

10.1158/1541-7786.25964895.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S15 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S15 and its legend.</p>

10.1158/1541-7786.25964904.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S16 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S16 and its legend.</p>

10.1158/1541-7786.25964901.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S5 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S5 and its legend.</p>

10.1158/1541-7786.25964874.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S11 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S11 and its legend.</p>

10.1158/1541-7786.25964919.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S7 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S7 and its legend.</p>

10.1158/1541-7786.25964868.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S1 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S1 and its legend.</p>

10.1158/1541-7786.25964925.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S8 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S8 and its legend.</p>

10.1158/1541-7786.25964865.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S17 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S17 and its legend.</p>

10.1158/1541-7786.25964898.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S12 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S12 and its legend.</p>

10.1158/1541-7786.25964916.v1 preprint EN cc-by 2024-06-04
 Supplementary Figure S6 from Serotonin Receptor HTR2B Facilitates Colorectal Cancer Metastasis via CREB1–ZEB1 Axis–Mediated Epithelial–Mesenchymal Transition
OPENALEX - Publications 
Tao Li Lei Wei Xin Zhang Bin Fu Yunjiang Zhou and 9 more Mengdi Yang Mengran Cao Yaxin Chen Yingying Tan Yongwei Shi Leyin Wu Chenyuan Xuan Qianming Du Rong Hu

<p>This file contains Supplementary Figure S6 and its legend.</p>

10.1158/1541-7786.25964871.v1 preprint EN cc-by 2024-06-04
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