A5093692229- Cellular Mechanics and Interactions
- Axon Guidance and Neuronal Signaling
- Erythrocyte Function and Pathophysiology
- Piperaceae Chemical and Biological Studies
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
Universidade Federal de Juiz de Fora
2024-2025
Glioblastoma (GBM) is a malignant brain tumor with diffuse infiltration. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 for confined migration through restricted space. Using live-cell imaging to track negotiating microchannels, reveal endocytic vesicle accumulation at cell front and filamentous actin assembly rear in polarized manner. These processes are interconnected require signaling. We further show that governs membrane tension other features such as endocytosis,...
ABSTRACT Glioblastoma (GBM) is a malignant brain tumor with uncontrolled invasive growth. Here, we demonstrate how GBM cells usurp guidance receptor Plexin-B2 to gain biomechanical plasticity for polarized migration through confined space. Using live-cell imaging track negotiating microchannels, reveal active endocytosis at cell front and filamentous actin assembly rear propel constrictions. These two processes are interconnected governed by that orchestrates cortical membrane tension, shown...