A5005080087- Neuroblastoma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Adrenal and Paraganglionic Tumors
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Ubiquitin and proteasome pathways
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
Iuliu Hațieganu University of Medicine and Pharmacy
2024
Institute of Oncology Prof. Dr. Ion Chiricuta
2024
University Hospital Cologne
2009-2010
University of Cologne
2009
Neuroblastoma serves as a paradigm for utilising tumour genomic data determining patient prognosis and treatment allocation. However, before the establishment of International Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, interpretation did not exist, compromising reliability decisive genetic markers inhibiting translational research efforts. The objectives INRG Biology Committee were to identify highly prognostic aberrations be included new risk...
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Macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is a rare and aggressive molecular subtype of (HCC) associated with poor prognosis. Unlike typical HCC, which commonly arises in the context cirrhosis, MTM-HCC can develop non-cirrhotic livers, presenting unique diagnostic therapeutic challenges. This case report describes 35-year-old male who presented persistent epigastric pain, fatigue, loss appetite. Clinical examination revealed hepatomegaly, prompting advanced imaging...
Background: Neuroblastoma serves as a paradigm for utilizing tumour genomic data determining patient prognosis and treatment allocation. However, prior to the establishment of International Risk Group (INRG) Task Force in 2004, international consensus on markers, methodology, interpretation did not exist, compromising reliability decisive genetic markers inhibiting translational research efforts. The objectives INRG Biology Committee were identify highly prognostic aberrations be included...
Background: Additional chromosomal material on the long arm of chromosome 17 (17q gain) is present in vast majority neuroblastomas (NB). Therefore it has been discussed as a first hit pathogenesis. In previous aCGH analysis 202 NB patients with resolution up to 15kb, we found small group (7%) without alterations 17q, but poor prognosis. We now reinvestigated this subgroup ultra-high-resolution arrays. Methods: Twelve tumors were analyzed by 1M median 2kb. Aberrations 1p and MYCN additionally...