Michael J. Melville

ORCID: 0009-0004-4414-9891
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About
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Research Areas
  • X-ray Diffraction in Crystallography
  • Crystallization and Solubility Studies
  • Molecular Sensors and Ion Detection
  • Luminescence and Fluorescent Materials
  • Covalent Organic Framework Applications
  • Nanoplatforms for cancer theranostics
  • Metal-Organic Frameworks: Synthesis and Applications
  • Conducting polymers and applications
  • Analytical Chemistry and Sensors

Colorado School of Mines
2023-2025

We present the synthesis, properties, and imaging applications of a new class diazaborine-based probes (Peroxynitrite Probe-1, PNP-1) for selective peroxynitrite (ONOO-) in live cells. PNP-1 features reaction motif that provides excellent discrimination between H2O2 ONOO-, solving persistent challenge organoboron-based fluorescent oxidative metabolite imaging. demonstrate utility to detect endogenously produced ONOO- RAW 264.7 macrophages by fluorescence microscopy, with probe selectivity...

10.1002/cbic.202400972 article EN ChemBioChem 2025-03-10

Systematic replacement of selenium for tellurium in a chalcogen-bonding tecton results divergent assembly behavior from competitive solvents.

10.1039/d3cc05162e article EN Chemical Communications 2023-12-21
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