A5007371084- Cardiac Ischemia and Reperfusion
- Sulfur Compounds in Biology
- Muscle and Compartmental Disorders
- Mitochondrial Function and Pathology
- Nutrition and Health in Aging
- Redox biology and oxidative stress
- Clinical Nutrition and Gastroenterology
- Abdominal Surgery and Complications
- Long-Term Effects of COVID-19
- Pulmonary Hypertension Research and Treatments
- Proteoglycans and glycosaminoglycans research
- Connective tissue disorders research
- Peptidase Inhibition and Analysis
- Electron Spin Resonance Studies
- Nitric Oxide and Endothelin Effects
Nanjing Medical University
2021-2022
Jiangsu Province Hospital
2022
Health First
2022
Myocardial ischemic/reperfusion (MI/R) is a leading cause of cardiovascular disease with high morbidity and mortality. However, the mechanisms underlying pathological reperfusion remain obscure. In this study, we found that dioscin, natural product, could be potential candidate for treating MI/R through modulating cardiac dysfunction. Mechanistically, our work revealed dioscin suppress production reactive oxygen species (ROS) via repressing nicotinamide adenine dinucleotide phosphate (NADPH)...
A 36-year-old male with congenital equinovarus deformity was admitted to the hospital due worsen deformity. He known have ear perforation in childhood. After hospitalization, he received correction surgery, fourth toe osteotomy, and external fixation for right foot during procedure. During his stay, patient has been treated multiple gastrointestinal perorations, accompanied organ dysfunction fragile soft tissues. in-hospital dysfunctions were observed, including heart, kidney, liver,...
This study aimed to explore the predictive value of single and multiple risk factors for clinical outcomes critically ill patients receiving enteral nutrition establish an effective evaluation model. Retrospective cohort study. Data from 2020-2021 period were collected electronic records First Affiliated Hospital, Nanjing Medical University. 459 with in geriatric intensive care unit included The primary outcome was 28-day mortality. secondary invasive mechanical ventilation time, stay,...
Abstract BACKGROUND: Sepsis-induced cardiomyopathy often leads to bad prognosis of patients, and even death. However, there is no effective therapeutic strategies for sepsis-caused cardiomyopathy. GYY4137 has positive effects in many diseases. The aim this study was explore the mechanism underlying sepsis-induced investigate protective role hydrogen sulfide (H 2 S) donor METHODS: Recruitment patients with clinical sepsis measurement serum H2S concentrations. administrated mouse model (SICM)...
Abstract BACKGROUNDSepsis-induced cardiomyopathy often leads to bad prognosis of patients, and even death. However, there is no effective therapeutic strategies for sepsis-caused cardiomyopathy. GYY4137 has positive effects in many diseases. The aim this study was explore the mechanism underlying sepsis-induced investigate protective role hydrogen sulfide (H 2 S) donor cardiomyopathy.METHODSGYY4137 administrated mouse model (SICM) generated by cecum ligation puncture (CLP), then plasma...