A5068862016- Spondyloarthritis Studies and Treatments
- Rheumatoid Arthritis Research and Therapies
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Autoimmune and Inflammatory Disorders Research
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Ocular Oncology and Treatments
- Acute Lymphoblastic Leukemia research
- Cytokine Signaling Pathways and Interactions
- Urticaria and Related Conditions
- Neuroblastoma Research and Treatments
- Immune Cell Function and Interaction
- Retinoids in leukemia and cellular processes
- Antifungal resistance and susceptibility
- Ocular Diseases and Behçet’s Syndrome
- Acute Myeloid Leukemia Research
- Fungal Infections and Studies
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Bone and Joint Diseases
- Nail Diseases and Treatments
- Otitis Media and Relapsing Polychondritis
- IgG4-Related and Inflammatory Diseases
- Corneal Surgery and Treatments
Guy's Hospital
2013-2025
St Thomas' Hospital
2014-2024
Guy's and St Thomas' NHS Foundation Trust
2011-2023
King's College London
2011-2022
Leiden University Medical Center
2022
The London College
2022
Universiti Sains Malaysia
1996-2021
Hospital Kuala Lumpur
2005-2018
King's College Hospital
2017
Center for Rheumatology
2016
Psoriatic arthritis (PsA) is associated with HLA class I genes, in contrast to the association II rheumatoid (RA). Since IL-17+ cells are considered important mediators of synovial inflammation, we sought determine whether IL-17-producing CD8+ T may be found joints patients PsA and these might contribute disease process.
BackgroundIndividuals with serum antibodies to citrullinated protein antigens (ACPA), rheumatoid factor, and symptoms, such as inflammatory joint pain, are at high risk of developing arthritis. In the arthritis prevention in pre-clinical phase abatacept (APIPPRA) trial, we aimed evaluate feasibility, efficacy, acceptability treating individuals T-cell co-stimulation modulator abatacept.MethodsThe APIPPRA study was a randomised, double-blind, multicentre, parallel, placebo-controlled, 2b...
T reg cells are critical for the prevention of autoimmune diseases and thus prime candidates cell‐based clinical therapy. However, human “plastic”, able to produce IL ‐17 under inflammatory conditions. Here, we identify characterize subpopulation that can be induced its mechanisms. We confirm a produces in vitro when activated presence ‐1β, but not ‐6. “ potential” is restricted population III ( CD 4 + 25 hi 127 lo 45 RA − ) Treg expressing natural killer cell marker 161. show these...
Two hundred and eighty-eight newly diagnosed cases of leukemia (164 males 124 females, 167 adults 121 children, 245 acute 43 chronic, 151 myeloid 137 lymphoid), aged between 6 weeks 78 years, were examined for eye changes in the oncology wards within 2 days diagnosis before starting chemotherapy. Ocular lesions present 102 patients (35.4%) – retinal vascular 91 (31.6%); infiltration ocular tissues 5 (1.7%), neuro-ophthalmic signs (2.1%) cases. Some had more than one lesion or both eyes. The...
Abstract Objective Despite the high frequency of CD4+ T cells with a regulatory phenotype (CD25+CD127 low FoxP3+) in joints patients rheumatoid arthritis (RA), inflammation persists. One possible explanation is that human Treg are converted into proinflammatory interleukin‐17 (IL‐17)–producing by inflammatory mediators and thereby lose their suppressive function. The aim this study was to investigate whether activated monocytes, which potent producers cytokines abundantly present rheumatic...
Objective Conflicting evidence exists regarding the suppressive capacity of Treg cells in peripheral blood (PB) patients with rheumatoid arthritis (RA). The aim this study was to determine whether are intrinsically defective RA. Methods Using a range assays on PB samples from chronic RA and healthy controls, CD3+CD4+CD25+CD127 low CD45RO+ or CD45RA+ T cell compartments were analyzed for phenotype, cytokine expression (ex vivo after vitro stimulation), suppression Teff proliferation...
To characterize the presentation and outcomes of patients with atopic dermatitis (AD) who developed musculoskeletal symptoms after treatment dupilumab, a human IgG4 monoclonal antibody that blocks functions interleukin-4 (IL-4) IL-13, key pathologic pathways in AD.This article reports an observational cohort receiving dupilumab new-onset therapy at our center. All had comprehensive rheumatologic history examination, imaging by ultrasonography (US) or magnetic resonance (MRI) most...
Objective Up to 40% of patients with inflammatory arthritis (IA) experience persistent pain, traditionally thought be associated a shift from peripheral centrally mediated pain during the disease course in some patients. We assessed sensory profiles recently diagnosed individuals IA, hypothesising that reported at this early stage diagnosis is driven predominantly by joint inflammation. Methods Recently IA numerical rating scale (NRS) scores 3 or more were recruited. collected data on:...
Abstract Background/Aims Up to 40% of patients with inflammatory arthritis (IA) experience persistent pain which, as the disease progresses, is likely be underpinned by distinct peripherally versus centrally mediated mechanisms. This study assessed sensory profiles recently diagnosed individuals IA, hypothesising that at this early stage primarily driven peripheral joint inflammation. Methods Patients a recent IA diagnosis and numerical rating scale (NRS) score ≥ 3 were recruited for study....
To determine the prevalence of ocular manifestations in childhood acute leukaemia at time presentation.Eighty-two children with were examined for lesions within two days diagnosis before starting chemotherapy. The detailed examination both eyes was carried out by ophthalmologist irrespective presence or absence eye symptoms all cases.Only 3 82 presented (3.6%). However, changes found 14 (17%); ten lymphoblastic and four myeloid leukaemia. observed proptosis, intraretinal haemorrhages, white...
In this prospective study, we examined stool specimens from children with cancer receiving chemotherapy who were admitted for fever to the Universiti Sains Malaysia Hospital in Kota Baru, Kelantan. Stool ova and cysts of parasites. Over a period 15 months, there 129 febrile episodes 50 and, all, 237 examined. Sixty-six per cent associated neutropenia 9 diarrhoea. parasites found 42 children. The most common helminths, followed by protozoa. Trichuris trichiura was parasite (24 cent), Ascaris...
The aims of this study were to review the presenting features, treatment and outcome for Malaysian children with retinoblastoma currently.This was a prospective study, conducted at General Hospital Kuala Lumpur from August 2001 until October 2007. Clinical data collected presentation follow-up.One hundred five diagnosed have retinoblastoma. There 55 males 50 females, ranging in age 1 month 14 years (median 20 months). Seventy-six Malay ethnic origin (73%), Chinese (13%), 12 Indian (11%),...
Background: Atopic dermatitis (AD) is a common skin condition with prevalence of 2–10% in adults 1 . IL-4 and IL-13 play key role the pathogenesis. Dupilumab, human IgG 4 monoclonal antibody binding alpha subunit receptor, blocking signaling, has important efficacy this difficult to treat disease. We first reported musculoskeletal (MSK) adverse effect enthesis/arthritis developing 3 patients 2019 2 Objectives: To report ongoing experience at our centre new clinical paradigm, incidence...
Undifferentiated, early inflammatory arthritis (EIA) can differentiate into seropositive or seronegative rheumatoid (RA), peripheral spondyloarthritis (SpA) remain as undifferentiated (UIA). Little is known about immune pathways active in the stages of SpA and UIA, contrast to detailed knowledge RA. The aim this study was examine if specific were synovial CD4+ CD8+ T cells EIA.Synovial fluid (SF) samples from 30 patients with EIA analysed for expression IL-17A, IFNγ TNFα cells. Final...
Two presentations at the Group for Research and Assessment of Psoriasis Psoriatic Arthritis (GRAPPA) 2023 annual meeting focused on unintended consequences immunomodulatory therapy psoriasis (PsO). Dr. Elizabeth Wallace presented tumor necrosis factor inhibitors treating PsO other inflammatory disorders. These include paradoxical PsO, which is defined as unexpected new cases or worsening symptoms seemingly induced by treatment. Bruce Kirkham dupilumab treatment, can a musculoskeletal...
In the last decade, chemotherapy in combination with focal therapy (chemoreduction) has been increasingly used intraocular retinoblastoma to avoid enucleation and radiotherapy. The aim of this study was assess feasibility outcome chemoreduction Malaysian children retinoblastoma. This a prospective from August 2001 January 2006. Twenty (25 eyes) were given 4 cycles chemoreduction, after which response assessed. Fourteen eyes showed complete response, 10 partial 1 eye had progressive disease....
The aims of this study were to review the deaths Malaysian pediatric oncology patients in order determine major causes and proportion who received palliative care.This was a retrospective from 2001-2007 at Pediatric Institute, General Hospital Kuala Lumpur. Clinical data such as age, gender, disease, cause, place death collected. divided into two groups: those care curative treatment.Two hundred forty-seven included. There 148 males 99 females. age ranged 2 months 22 years (median, 4 years)....
Down syndrome may be associated with many complications. Among the malignancies syndrome, leukaemia is most common. This a case report of patient both retroperitoneal teratoma and Morgagni hernia.
Despite the high frequency of CD4+ T cells with a regulatory phenotype (CD25+CD127lowFoxP3+) in joints patients rheumatoid arthritis (RA), inflammation persists. Regulatory (Tregs) can be converted into pro-inflammatory IL-17-producing by inflammatory mediators, particularly IL-1β.