A5049892896- Environmental Toxicology and Ecotoxicology
- Advanced biosensing and bioanalysis techniques
- Potato Plant Research
- Pharmaceutical and Antibiotic Environmental Impacts
- SARS-CoV-2 and COVID-19 Research
- Zebrafish Biomedical Research Applications
- Reproductive biology and impacts on aquatic species
- RNA Interference and Gene Delivery
- Plant Pathogens and Resistance
- SARS-CoV-2 detection and testing
- Sesame and Sesamin Research
- Pesticide and Herbicide Environmental Studies
- Supramolecular Self-Assembly in Materials
Helmholtz Centre for Environmental Research
2023-2024
Fraunhofer Institute for Cell Therapy and Immunology
2022-2023
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD) is a widely used antioxidant in tire rubber known to enter the aquatic environment via road runoff. The associated transformation product (TP) 6-PPD quinone (6-PPDQ) causes extreme acute toxicity some fish species (e.g., coho salmon). To interpret species-specific toxicity, information about biotransformation products of 6-PPDQ would be relevant. This study investigated toxicokinetics and zebrafish embryo (ZFE) model. Over 96 h...
Acrylamides are widely used industrial chemicals that cause adverse effects in humans or animals, such as carcinogenicity neurotoxicity. The excess toxicity of these reactive electrophilic is especially interesting, it mostly triggered by covalent reactions with biological nucleophiles, DNA bases, proteins, peptides. cytotoxicity and activation oxidative stress response 10 (meth)acrylamides measured three reporter gene cell lines occurred at similar concentrations. Most acrylamides exhibited...
Binding interactions of the spike proteins severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) to a peptide fragment derived from human angiotensin converting enzyme (hACE2) receptor are investigated. The is employed as capture moiety in linked immunosorbent assays (ELISA) and quantitative binding interaction measurements that based on fluorescence proximity sensing (switchSENSE). In both techniques, presented an oligovalent DNA nanostructure, order assess impact mono- versus...
Internal concentrations (ICs) are crucial for linking exposure to effects in the development of New Approach Methodologies. ICs chemicals aquatic organisms primarily driven by hydrophobicity and modulated biotransformation efflux. Comparing predicted baseline observed toxicity enables estimation effect specificity, but biological processes can lead overestimating bias specificity assessment. To evaluate prediction a mass balance model (MBM) impact on ICs, experimental 63 zebrafish embryos...