A5045679854- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Prenatal Screening and Diagnostics
- 3D Printing in Biomedical Research
- Vibrio bacteria research studies
- RNA and protein synthesis mechanisms
- Legume Nitrogen Fixing Symbiosis
- Genomics and Chromatin Dynamics
- Bacterial Genetics and Biotechnology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Antenna Design and Analysis
- Cystic Fibrosis Research Advances
- Global Cancer Incidence and Screening
- Genomic variations and chromosomal abnormalities
- Prostate Cancer Treatment and Research
- Renal and related cancers
- Nutrition, Genetics, and Disease
- Aerosol Filtration and Electrostatic Precipitation
- BRCA gene mutations in cancer
National Taiwan University
2016-2021
University of California, Los Angeles
2014-2017
California NanoSystems Institute
2014-2017
Sanford Health
2017
University of California, San Diego
2017
University of California, Davis
2017
University of California, Irvine
2017
University of California, San Francisco
2017
Unlike tumor biopsies that can be constrained by problems such as sampling bias, circulating cells (CTCs) are regarded the "liquid biopsy" of tumor, providing convenient access to all disease sites, including primary and fatal metastases. Although enumerating CTCs is prognostic significance in solid tumors, it conceivable performing molecular functional analyses on will reveal much significant insight into biology guide proper therapeutic intervention. We developed Thermoresponsive...
BACKGROUND Although enumeration of circulating tumor cells (CTCs) has shown some clinical value, the pool CTCs contains a mixture that additional information can be extracted. The authors subclassified by shape features focusing on nuclear size and related this with information. METHODS A total 148 blood samples were obtained from 57 patients prostate cancer across spectrum metastatic states: no metastasis, nonvisceral visceral metastasis. captured enumerated NanoVelcro Chips (CytoLumina,...
Circulating fetal nucleated cells (CFNCs) in maternal blood offer an ideal source of genomic DNA for noninvasive prenatal diagnostics (NIPD). We developed a class nanoVelcro microchips to effectively enrich subcategory CFNCs, i.e., circulating trophoblasts (cTBs) from blood, which can then be isolated with single-cell resolution by laser capture microdissection (LCM) technique downstream genetic testing. first established nanoimprinting fabrication process prepare the LCM-compatible...
The design principle of establishing an intracellular protein gradient for asymmetric cell division is a long-standing fundamental question. While the major molecular players and their interactions have been elucidated via genetic approaches, diversity redundancy natural systems complicate extraction critical underlying features. Here, we take synthetic biology approach to construct asymmetry in Escherichia coli, which normally symmetric. We demonstrate that oligomeric PopZ from Caulobacter...
Siderophores are small molecules used to specifically transport iron into bacteria via related receptors. By adapting siderophores and hijacking their pathways, we may discover an efficient selective way target microbes. Herein, report the synthesis of a siderophore-fluorophore conjugate VF-FL derived from vibrioferrin (VF). Using flow cytometry fluorescence microscopy, probe selectively labeled vibrios, including V. parahaemolyticus, cholerae, vulnificus, even in presence other species such...
Abstract Background Circulating tumor cells (CTCs) are an emerging biomarker in prostate cancer (PC). Most efforts have focused on enumeration, we and others identified subsets within this pool of which may be clinically informative. Using the highly sensitive NanoVelcro technology for CTC isolation fluorescence microscopy, our group sub-classified CTCs by nuclear size correlation with sites metastatic disease advanced PC patients. Methods Blood samples were obtained from patients across...
Abstract Background: The WISDOM Study (Women Informed to Screen Depending on Measures of risk) aims examine the effectiveness personalized breast cancer screening and bring objective recommendations current mammography debate. is a 100,000 woman randomized trial with preference-tolerant design that will determine if risk-based (RBS) vs. annual screening, as safe, less morbid, enables prevention preferred by women. A pilot was conducted test logistics online participation acceptance study...