A5094259937- Renal Transplantation Outcomes and Treatments
- Renal Diseases and Glomerulopathies
- Blood groups and transfusion
- Atherosclerosis and Cardiovascular Diseases
- Complement system in diseases
- Renal and Vascular Pathologies
- Monoclonal and Polyclonal Antibodies Research
- Blood transfusion and management
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Transplantation: Methods and Outcomes
- T-cell and B-cell Immunology
- Immune cells in cancer
- Immunodeficiency and Autoimmune Disorders
- Cytomegalovirus and herpesvirus research
- Vasculitis and related conditions
- Renal cell carcinoma treatment
- S100 Proteins and Annexins
- Organ Transplantation Techniques and Outcomes
University Hospital of Zurich
2023-2025
Background. Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity. However, their utility in cases additional diagnoses other than remains inadequately studied. Methods. In our comprehensive analysis of 326 kidney allograft biopsies, assessed by histology and the Molecular Microscope Diagnostic System, we identified 68 characterized pathologies, including pyelonephritis (n = 15), BK nephropathy 20), acute interstitial...
Isolated Tubulitis, Borderline Changes, and Arteritis suspicious for histologic T cell-mediated rejection (hTCMR) remain findings of uncertain significance. Although the Molecular Microscope Diagnostics System (MMDx) has not been trained on those lesions, it was suggested that MMDx might reclassify a subgroup to molecular TCMR (mTCMR).
Abstract Background and Aims Biopsy based transcript diagnostics using the molecular microscope diagnostic system (MMDx) have potential to add clarification in antibody mediated rejection (AMR) continuum. While de novo donor specific (dnDSA) or preformed DSA accompanied by allograft function deterioration are accepted indications for biopsy with therapeutic implications, management strategy subclinical lacks consensus. MMDx might show clinical utility this controverse scenario helping...
Abstract Background and Aims Biopsy-based transcripts associated with antibody-mediated rejection (AMR) hold promise as substitutes for C4d positivity, according to the latest Banff Meeting Report of 2022. However, patterns strength phenotype scores remain inadequately studied within new subgroups along AMR continuum. Method We analyzed 365 kidney allograft biopsies by histology Molecular Microscope Diagnostic System (MMDx) at University Hospital Zurich from July 2021 November 2023....
Schachtner, Thomas; Weidmann, Lukas; Harmacek, Dusan; López, Kai C.; Korach, Raphael; Bortel, Nicola; Mueller, Thomas F. Author Information
Schachtner, Thomas; López, Kai C.; Weidmann, Lukas; Harmacek, Dusan; Bortel, Nicola; Korach, Raphael; Mueller, Thomas F. Author Information
Schachtner, Thomas; Weidmann, Lukas; Harmacek, Dusan; López, Kai C.; Bortel, Nicola; Korach, Raphael; Mueller, Thomas F. Author Information
Schachtner, Thomas; Moos, Seraina C. Von; López, Kai C.; Weidmann, Lukas; Harmacek, Dusan; Bortel, Nicola; Korach, Raphael; Mueller, Thomas F. Author Information
Schachtner, Thomas; Weidmann, Lukas; Harmacek, Dusan; Bortel, Nicola; López, Kai C.; Korach, Raphael; Mueller, Thomas F. Author Information
Schachtner, Thomas; Weidmann, Lukas; Harmacek, Dusan; Korach, Raphael; Bortel, Nicola; López, Kai C.; Mueller, Thomas F. Author Information
Schachtner, Thomas; Weidmann, Lukas; Harmacek, Dusan; Bortel, Nicola; López, Kai C.; Korach, Raphael; Mueller, Thomas F. Author Information