A5035540803- Carbohydrate Chemistry and Synthesis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Glycosylation and Glycoproteins Research
- Synthetic Organic Chemistry Methods
- Chemical synthesis and alkaloids
- Chemical Synthesis and Analysis
- Marine Sponges and Natural Products
- Natural product bioactivities and synthesis
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Agricultural pest management studies
- Natural Compound Pharmacology Studies
- Synthesis of Organic Compounds
- Metabolism, Diabetes, and Cancer
- Plant biochemistry and biosynthesis
- Synthesis and Biological Activity
- Tuberculosis Research and Epidemiology
- Phytochemistry and Biological Activities
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Synthesis and Catalytic Reactions
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Chemical Synthesis and Reactions
Government Medical College
2019-2024
Bristol-Myers Squibb (United States)
2003-2023
AIDS Society of India
2023
International Institute for Population Sciences
2023
Honeywell (India)
2021
Bristol-Myers Squibb (Germany)
2002-2014
Texas A&M University – Kingsville
2007
Villanova University
2005
Kettering University
1997-2002
Columbia University
1998
The C-aryl glucoside 6 (dapagliflozin) was identified as a potent and selective hSGLT2 inhibitor which reduced blood glucose levels in dose-dependent manner by much 55% hyperglycemic streptozotocin (STZ) rats. These findings, combined with favorable ADME profile, have prompted clinical evaluation of dapagliflozin for the treatment type 2 diabetes.
A practical synthesis of the SGLT-2 inhibitor β-C-aryl-d-glucoside (1) has been developed. The route employed 2,3,4,6-tetra-O-trimethlysilyl-d-glucano-1,5-lactone as key chiral building block, prepared efficiently from commercially available, inexpensive raw materials, d-gluconolactone and trimethylsilyl chloride. salient step in is Lewis acid-mediated stereoselective reduction a methyl C-aryl peracetylated glycoside using silyl hydride to set stereochemistry crucial anomeric center. Several...
A concise and potentially practical synthesis of the title compound has been achieved. The route features a high degree convergence economy synthetic operations. key step is concurrent introductory addition three α-l-fucosyl residues at required hydroxyl acceptor sites (see 37 → 39). Conjugation to carrier protein was achieved, include truncated structures for investigations antibody specificity accomplished.
An efficient and practical process to generate beta-C-arylglucoside derivatives was achieved. The described involves Lewis acid mediated ionic reduction of a peracetylated 1-C-aryl methyl glucoside derived from the addition an aryl-Li selectively protected delta-D-gluconolactone. 2-acetoxy-1-C-oxacarbenium ion intermediates proceeds with high degree selectivity give beta-C-arylglucosides without 2-acetoxy group participation. Furthermore, during we also identified unprecedented critical role...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Optically Active Calanolides A and BPrashant P. Deshpande, Frank Tagliaferri, Samuel F. Victory, Shija Yan, David C. BakerCite this: J. Org. Chem. 1995, 60, 10, 2964–2965Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 1995https://pubs.acs.org/doi/10.1021/jo00115a007https://doi.org/10.1021/jo00115a007research-articleACS PublicationsRequest reuse permissionsArticle...
Optically pure enone 9c, available in three steps from known 6-deoxy d-galactal derivative 7b, reacts with cyanophthalide 6 to directly afford the natural product (−)-hongconin (1), a compound traditional Chinese medicine recently shown exhibit antianginal activity. The enantiomer of 1 and its (+)-cis-diastereomer were also synthesized parallel fashion l-sugar counterpart. use C-glycoside Michael acceptors, as opposed their O-glycoside counterparts, represents potentially useful...
Abstract There is mounting evidence to suggest that immunization‐based strategies can be used mobilize the human immune system against specific carbohydrate antigens displayed on surface of cancer cells. Following isolation and identification, such administered as conjugate vaccines. The tumor‐associated antigen KH‐1 1 may serve a potential target for immunization adenocarcinoma. However, serious impediment application vaccine‐based approach involving this its availability from natural...
Reaction of anhydrous silver perchlorate, sym-collidine, and iodine (2:1:1 molar ratio) with cyclic alkenes an excess alcohol in CH2Cl2 affords trans-1,2-dialkoxycycloalkanes high yields purity. The reaction occurs via initial formation the trans-iodoethers, which undergo Ag-assisted iodide abstraction to give trans-diethers.
An efficient, stereoselective synthesis of 4′-Ed4T is demonstrated. The highlighted by a regioselective TMSOTf-mediated acetal opening, Claisen rearrangement to set the key 4′-stereocenter as well olefin, and one-pot nonaflation/elimination deliver alkyne moiety. proceeds in eight steps from 5-methyluridine occurs 37% overall yield.
It is important to understand the current internet-related sexual behaviours of high-risk groups such as men who have sex with (MSM). We designed present study types online/mobile apps used by MSM and male-to-female transgendered people/hijras [TGH] in Mumbai, India. also compared 'partner seeking' 'sexual behaviours' TGH India.This a cross-sectional analysis secondary data collected (April June 2020) from 8582 4163 five targeted intervention programmes each Maharashtra, Data on...
In this paper, a (PF) Power factor correction and power quality (PQ) improvement based BLDC motor drive proposed. Normally the permanent magnet connected with diode bridge rectifier high value of capacitor due to which poor higher THD (Total harmonic distortion) at input side To overcome difficulty SEPIC (Single-ended primary inductance converter) converter use optimize PF value. The operates in discontinuous conduction mode get desired result. This scheme also used for speed control by...
People with Advanced HIV Disease (AHD) are at higher risk of TB coinfection and mortality. However, there challenges in diagnosis the currently recommended diagnostic tools. WHO recommends lateral flow urine lipoarabinomannan (LF-LAM) assay to assist among AHD patients. We assessed utility acceptability using LF-LAM for patients public Antiretroviral Therapy (ART) Centres Mumbai. The cross-sectional study was conducted adult accessing care from 17 ART centres during November,2020-June, 2021....
The 2-nitramino functionality in 2-nitramino-4-picoline was successfully exploited not only as a protecting group but also directional handle to afford an efficient, atom-economic, and regioselective synthesis of 2-amino-5-bromo-3-nitro-4-picoline (4), precursor for drug candidate development.