A5062982701- Hemoglobinopathies and Related Disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- Blood properties and coagulation
- Eosinophilic Disorders and Syndromes
- Cardiac Arrhythmias and Treatments
- Acute Myeloid Leukemia Research
- Cardiovascular Syncope and Autonomic Disorders
- Iron Metabolism and Disorders
- MRI in cancer diagnosis
University College London Hospitals NHS Foundation Trust
2024-2025
University College London
2024-2025
University College Hospital
2024
St George's Hospital
2022
ABSTRACT Introduction Myeloproliferative neoplasms (MPNs), such as polycythaemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF), are primarily treated by managing blood counts to reduce the thrombotic risk using cytoreductive agents. Busulphan, an oral alkylating agent, has been historically used for MPN management due its myelosuppressive effects, but concerns about of leukaemic transformation have limited use. Methods This real‐world retrospective study evaluated safety...
Left ventricular systolic dysfunction (LVSD) is an uncommon but life-threatening complication of sickle cell disease (SCD), with poorly characterized aetiology. We present three SCD patients LVSD due to different underlying mechanisms.
<h3>Background</h3> Sickle cell disease (SCD) is an inherited haemoglobinopathy characterised by recurrent vaso-occlusive crises and chronic haemolytic anaemia. Amongst the cardiac complications related to SCD, left ventricular systolic dysfunction (LVSD) uncommon, poorly characterised, but life-threatening complication. <h3>Purpose</h3> To characterise using MRI (CMR) varying phenotypes of LVSD complicating SCD. <h3>Methods</h3> We conducted a retrospective evaluation 20 SCD patients with...
This case report highlights the importance of recognizing that ventricular ectopy may be a cause for syncope and sudden cardiac death, through triggered disorganized arrhythmia. In context syncope, should carefully assessed coupling interval morphology.A 39-year-old woman, who had presented with recurrent arrest shortly after admission required emergency defibrillation. Review her monitoring revealed an episode polymorphic tachycardia which degenerated into fibrillation. The dysrhythmia been...