A5104668320- Retinal Diseases and Treatments
- Proteoglycans and glycosaminoglycans research
- Retinal and Macular Surgery
- Pancreatic function and diabetes
- Neurological Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Blood properties and coagulation
- Protease and Inhibitor Mechanisms
- Diabetes and associated disorders
- Vasculitis and related conditions
- Acute Ischemic Stroke Management
- Cell Adhesion Molecules Research
- Biochemical effects in animals
- Infectious Diseases and Tuberculosis
- Intracranial Aneurysms: Treatment and Complications
- Polysaccharides and Plant Cell Walls
- Hippo pathway signaling and YAP/TAZ
- Cerebrovascular and Carotid Artery Diseases
- Intraocular Surgery and Lenses
- Endoplasmic Reticulum Stress and Disease
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Advanced Glycation End Products research
- Medicinal Plants and Bioactive Compounds
- Diabetes, Cardiovascular Risks, and Lipoproteins
Chinese PLA General Hospital
2021-2024
Chinese People's Liberation Army
2023-2024
The 309th Hospital of Chinese People's Liberation Army
2009-2016
Shank3, a key molecule related to the development and deterioration of autism, has recently been found downregulate in murine brain after ischemia/reperfusion (I/R). Despite this discovery, however, its effects on neuronal injury mechanism underlying remain be clarified. To address this, study, based genetically modified mice models, we revealed that expression Shank3 showed time-dependent change hippocampal neurons I/R, conditional knockout (cko) resulted aggravated injuries. The protective...
Background and Purpose Retinopathy, as a common complication of diabetes, is leading cause reduced visual acuity acquired blindness in the adult population. The aim present study was to investigate therapeutic effect hydrogen sulfide on streptozotocin ( STZ )‐induced diabetic retinopathy rats. Experimental Approach Rats were injected with single i.p. injection (60 mg·kg −1 ) induce retinopathy. Two weeks later, rats treated NaHS (i.p. 0.1 mL ·kg ·d 0.28 mol· L , donor H 2 S for 14 weeks. Key...
Abstract Background Atherosclerosis is a chronic degenerative disease of the arteries and thought to be one most common causes death globally. In recent years, functions adventitial fibroblasts in development atherosclerosis tissue repair have gained increased interests. LPS can increase morbidity mortality atherosclerosis-associated cardiovascular disease. Although increases neointimal via TLR4 activation has been reported, how augments atherogenesis through acting on still unknown. Here we...
(1) To evaluate the association between expression of α-smooth muscle actin (α-SMA) in proliferative vitreoretinopathy (PVR) and pathological grading PVR, effect platelet-derived growth factor (PDGF) on α-SMA by human retinal pigment epithelial (RPE) cells. (2) investigate potential induction PDGF proliferation migration RPE cells as well signaling pathways responsible.We immunohistochemically investigated PVR. further downstream signaling, exogenous PDGF-BB inhibitors were added to cultured...
Type 1 diabetes (T1D), an autoimmune disease, occurs most commonly in children. Identifying altered gene expression peripheral blood mononuclear cells (PBMCs) of T1D may lead to new strategies for preserving or improving β-ell function patients with T1D.The Gene Expression Omnibus database was searched microarray studies PBMCs T1D. Subsequently, datasets from multiple were integrated obtain differentially expressed genes (DEGs) between and normal controls (NC). analysis performed determine...
With the extensive use of carotid artery stenting (CAS) surgeries, scholars are paying more attention to safety and efficiency CAS. Our study aims analyze clinical efficiency, safety, technical feasibility CAS surgery in treatment stenosis. A total 379 cases were collected retrospectively analyzed. The outcomes summarized according decrease stenosis extent, incidence early complications after procedure, 30-day end point events, follow-up data. Logistic regression was employed correlations...
To characterize the clinical and imaging features of circumscribed choroidal hemangioma (CCH), to evaluate individualized treatment efficiency photodynamic therapy (PDT), transpupillary thermotherapy (TTT), or their combination, followed by retrobulbar injection betamethasone on CCH resolvement. Forty-nine patients with CCHs who underwent PDT, TTT PDT+TTT treatments were retrospectively analyzed. Their efficacy was compared analyzing change best corrected visual acuity (BCVA), subretinal...
Objective To analyze the characteristics of retinal pigment epithelium (RPE) tears following injection intravitreal anti-vascular endothelial growth factor (VEGF) for treatment age-related macular degeneration (AMD). Methods A comprehensive literature review RPE anti-VEGF therapy AMD was conducted using PubMed and CBM disc databases, features were summarized. Results total 35 studies from included. The average age patients who developed 78.6 years (range 59-96 years), times before 1.6 1-4)....