A5114930071- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Plant Stress Responses and Tolerance
- Kruppel-like factors research
- Machine Learning in Healthcare
- Plant Molecular Biology Research
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Plant responses to water stress
- Blood Coagulation and Thrombosis Mechanisms
Jilin University
2023-2024
First Hospital of Jilin University
2023-2024
Sanya University
2023
Hainan University
2023
Shenyang Medical College
2022
Recent observational studies have reported the association between ischemic stroke (IS) and cerebral microbleeds (CMBs). Whether this reflects a causal remains to be established. Herein, we adopted two-sample bidirectional Mendelian randomization (MR) analysis comprehensively evaluate of IS CMBs.The summary-level genome-wide (GWASs) data were obtained from GIGASTROKE consortium (62,100 European ancestry cases 1,234,808 controls). All could further divided into large-vessel atherosclerosis...
Lactate dehydrogenase (LDH), a nonspecific inflammatory biomarker, has been used in the assessment of acute myocardial infarction, hepatitis, lung injury, and other severe diseases. However, no studies have evaluated prognostic value LDH patients with non-traumatic intracerebral hemorrhage (ICH). This cohort study aims to assess association between levels 28-day all-cause mortality ICH. Data for this retrospective analysis were obtained from MIMIC-IV (v2.2) database, included ICH as defined...
Salinity is an important environmental factor influencing crop growth and yield. Malate dehydrogenase (MDH) catalyses the reversible conversion of oxaloacetate (OAA) to malate. While many MDHs have been identified in various plants, biochemical function MDH rice remains uncharacterised, its role salt stress response largely unexplored. In this study, OsMDH12 was determined, revealing involvement regulating tiller number tolerance rice. localises peroxisome expressed across organs. vitro...
Parkinson's disease (PD) is a well-known neurodegenerative disorder associated with high risk in middle-aged and elderly individuals, severely impacting the patient's quality of life. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) frequently used to establish PD animals. Dendritic spines are dendritic processes that form foundation learning memory. Reportedly, spine density striatal medium spiny neurons (MSNs) declines PD, this decline has been progression; however, underlying mechanism...
<title>Abstract</title> Background Evidence of the genetic interconnectedness between thrombomodulin levels (TM) and stroke is largely unclear. This study aims to explore relationship predisposition TM with a 2-sample, bidirectional Mendelian randomization (MR) method. Methods Genetic instruments for each stroke-related phenotypes were derived from large-scale genome-wide association studies. The inverse variance weighted method was used in primary analyses obtain causal estimates....