A5010262495- Cardiac Ischemia and Reperfusion
- Drug Transport and Resistance Mechanisms
- Immune Response and Inflammation
- Pomegranate: compositions and health benefits
- Heart Failure Treatment and Management
- Neonatal Health and Biochemistry
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Pediatric Hepatobiliary Diseases and Treatments
- Endoplasmic Reticulum Stress and Disease
- Cynara cardunculus studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Pharmacological Effects of Natural Compounds
- Immune cells in cancer
- Liver Disease and Transplantation
- Phytochemicals and Antioxidant Activities
- Abdominal Surgery and Complications
- Cardiac Imaging and Diagnostics
- Chemotherapy-induced cardiotoxicity and mitigation
- Takotsubo Cardiomyopathy and Associated Phenomena
- Sphingolipid Metabolism and Signaling
- Liver Diseases and Immunity
- Abdominal vascular conditions and treatments
- Neuropeptides and Animal Physiology
- Gastroesophageal reflux and treatments
University of Banja Luka
2023-2025
Western University of Health Sciences
2024
Introduction This study aimed to investigate the anti-inflammatory, antioxidant, and anti-apoptotic properties of ursodeoxycholic (UDCA) chenodeoxycholic (CDCA) bile acids in a rat model endotoxin (lipopolysaccharide, LPS)-induced acute lung injury (ALI). Methods The included six groups Wistar rats exposed different pretreatments. control were pretreated with propylene glycol, solvent for acids, while other received UDCA or CDCA 10 days. On 10th day, an injection was given evaluate impact...
Abstract Background Isoprenaline (ISO), a synthetic catecholamine and β-adrenoceptor agonist, is widely used to develop an experimental model of myocardial injury (MI) in rats. The leading hypothesis for ISO-induced MI rats that it results from overstimulation, oxidative stress, inflammatory responses, development cardiomyopathy during ISO administration. Folic acid (FA) reduces improves endothelial function prevents apoptosis, thereby contributing cardiovascular protection. This study aimed...
Abstract Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes endothelial cells, that lead to tissue injury organ failure. aim of this study was explore the anti-inflammatory, antioxidant, cytoprotective properties two bile acids, ursodeoxycholic acid (UDCA) chenodeoxycholic (CDCA) in LPS-induced...
Type 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease, especially myocardial injury. Due to their hypoglycemic effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are efficiently used for T2DM management. GLP-1RAs also have anti-inflammatory and antioxidative effects can improve cardiac function. The aim this study was investigate cardioprotective liraglutide, a GLP-1RA, on isoprenaline-induced injury in rats. included four groups animals. They were...
Background: Myocardial injury (MI) is characterized by an increased level of at least one cardiac troponin. Experimental MI can be induced isoprenaline, a β-adrenergic agonist, and it lead to heart failure (HF). Liraglutide glucagon-like 1 peptide receptor agonist used in diabetes management, but has anti-inflammatory antioxidative effects, which beneficial treatment HF. The aim this study was investigate the effects liraglutide on isoprenaline-induced prevention Methods: Male Wistar albino...
Diabetes mellitus and inflammatory bowel disease are chronic conditions with significant overlap in their pathophysiology, primarily driven by inflammation. Both diseases characterized an aberrant immune response disrupted homeostasis various tissues. However, it remains unclear which develops first, one contributes to the other. increases risk of may increase developing diabetes. This review focuses on comprehensively discussing factors commonly contributing pathogenesis diabetes draw a...
Background/Aim: Due to the numerous beneficial effects of pomegranate that can be explained through its antioxidative effects, aim this study was determine antioxidant potential peel extract (PoPEx) prepared from harvested in southeast region Herze-govina (Bosnia and Herzegovina), vitro vivo studies. Methods: In PoPEx total phenols, flavonoids, flavonols, flavan-3-ols antho-cyanins content determined, as well several assays, including 2,2 diphenyl-1-picrylhydrazyl assay (DPPH), 2,2'-azino...
Takotsubo syndrome (TTS) is an acute heart failure characterised by catecholamine-induced oxidative tissue damage. Punica granatum, a fruit-bearing tree, known to have high polyphenolic content and has been proven be potent antioxidant. This study aimed investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats. Male Wistar rats were randomised into four groups. Animals PoPEx(P) PoPEx + isoprenaline group (P I)...
Abstract Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes endothelial cells, that lead to tissue injury organ failure. aim of this study was explore the anti-inflammatory, antioxidant, cytoprotective properties two bile acids, ursodeoxycholic acid (UDCA) chenodeoxycholic (CDCA) in LPS-induced...
Inflammatory bowel disease (IBD), encompassing Crohn's and ulcerative colitis, is a chronic relapsing condition characterized by persistent inflammation of the gastrointestinal tract. The complex pathogenesis IBD involves combination genetic, environmental, immune factors, which complicates achievement long-term remission. Lower abdominal pain, stomach cramps, blood in stool, diarrhea, fatigue, unexpected weight loss are common presenting symptoms. Despite range therapies medications,...
Acute mesenteric ischaemia (AMI) is a serious disease with mortality between 50 and 80 %. Oxidative stress plays major role in the pathophysiology of AMI. AMI should be considered for any acute abdominal pain that requires analgesia morphine which no other obvious aetiology found. CT main diagnostic procedure to confirm diagnosis There specific biomarker can used routine practice. an urgent therapeutic situation. Treatment includes protocol combining digestive rest, curative anticoagulant,...