A5092947021- Catalytic C–H Functionalization Methods
- Asymmetric Hydrogenation and Catalysis
- Synthesis and Catalytic Reactions
- Oxidative Organic Chemistry Reactions
- Catalytic Cross-Coupling Reactions
- Radical Photochemical Reactions
- Axial and Atropisomeric Chirality Synthesis
- Crystallization and Solubility Studies
- CO2 Reduction Techniques and Catalysts
- Cyclopropane Reaction Mechanisms
- Synthesis of Indole Derivatives
- Carbon dioxide utilization in catalysis
University of Göttingen
2023-2025
Paderborn University
2024
Abstract The assembly of chiral molecules with multiple stereogenic elements is challenging, and, despite indisputable advances, largely limited to toxic, cost-intensive and precious metal catalysts. In sharp contrast, we herein disclose a versatile C–H alkylation using non-toxic, low-cost iron catalyst for the synthesis substituted indoles two elements. key achieving excellent diastereo- enantioselectivity was substitution on N -heterocyclic carbene ligand providing steric hindrance extra...
Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced materials. Particularly development ligands has significantly efficiency selectivity transition metal-catalyzed enantioselective transformations. Over recent decades, numerous ligand classes with distinct geometrical electronic properties were established. Despite these advances, demand for novel, tunable, highly effective persist, driven by need...
Enantioselective electrocatalyzed C–H activations have emerged as a transformative platform for the assembly of value-added chiral organic molecules. Despite recent progress, construction multiple C(sp3)-stereogenic centers via C(sp3)–C(sp3) bond formation has thus far proven to be elusive. In contrast, we herein report an annulative activation strategy, generating Fsp3-rich molecules with high levels diastereo- and enantioselectivity. κ2-N,O-oxazoline preligands were effectively employed in...
Enantioselective electrocatalyzed C−H activations have emerged as a transformative platform for the assembly of value-added chiral organic molecules. Despite recent progress, construction multiple C(sp3)-stereogenic centers via C(sp3)−C(sp3) bond formation has thus far proven elusive. In contrast, we herein, report an annulative activation strategy, generating Fsp3-rich molecules with high levels diastereo-and enantio-selectivity. We employed novel κ2-N,O-oxazoline preligands first time in...
Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced materials. Particularly, development ligands has significantly efficiency selectivity transition metal‐catalyzed enantioselective transformations. Over recent decades, numerous ligand classes with distinct geometrical electronic properties have been established. Despite these advances, demand for novel, tunable, highly effective persists, driven by need...
Ortho-/pseudo-Disubstituted multi-chiral [2.2]paracyclophanes (PCPs) represent privileged scaffolds for asymmetric catalysis, finding extensive applications as chiral ligands in organic synthesis and functional materials. However, enantioselective C–H activation strategies accessing these structurally demanding molecules remain largely underexplored. We report a synergistic strategy combining photoredox catalysis with cobalt-catalyzed C−H that enables efficient construction of central planar...
Abstract Enantioselective electrocatalysis bears unique potential for the sustainable assembly of enantiomerically enriched molecules 1–7 . This approach allows electro-oxidative C–H activation to be performed paired hydrogen evolution reaction 8,9 While recent progress featured scarce transition metals with limited availability 10–17 , we, herein, reveal that Earth-abundant 3d transition-metal nickel is characterized by performance, while having high natural abundance 18 and reduced...
We report the synthesis of dianionic OCO-supported NHC and MIC complexes molybdenum tungsten with general formula (OCO)MO2 (OCO = bis-phenolate benzimidazolylidene M Mo (1-Mo), triazolylidene (2-Mo), W (2-W) imidazolylidene, (3-Mo), (3-W)). These are tested in catalytic deoxygenation nitroarenes using pinacol as a sacrificial oxygen atom acceptor/reducing agent to examine influence carbene metal centre this transformation. The results show that molybdenum-based complex 2-Mo is by far most...