A5091211777- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Photoreceptor and optogenetics research
- Trace Elements in Health
- Infectious Encephalopathies and Encephalitis
- RNA regulation and disease
- Nicotinic Acetylcholine Receptors Study
- Neuroinflammation and Neurodegeneration Mechanisms
École Polytechnique Fédérale de Lausanne
2017-2024
The CA1 region of the hippocampus is one most studied regions rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth experimental data on its structure function, it has been challenging integrate information obtained from diverse approaches. To address this challenge, we present community-based, full-scale silico model rat that integrates broad range data, synapse network, including reconstruction principal afferents,...
Abstract The CA1 region of the hippocampus is one most studied regions rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth experimental data on its structure function, it has been challenging reconcile information obtained from diverse approaches. To address this challenge, we present community-driven, full-scale silico model rat that integrates broad range data, synapse network, including reconstruction principal...
Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models simulations enable predictions on the potential role of ACh reconfiguring network activity. As a prelude into investigating how cellular effects collectively influence emergent dynamics, we developed data-driven framework incorporating phenomenological physiology cholinergic modulation neocortical cells synapses. The...
Abstract The vast majority of cortical synapses are found in the neuropil which is implicated multiple and diverse functions underlying brain computation. Unraveling organizing principles requires an intricate characterization synaptic connections established by excitatory inhibitory axon terminals, intrinsic extrinsic origin from ascending projections that govern function microcircuits through release neuromodulators either point-to-point chemical or diffuse volume transmission (VT). Even...
OPINION article Front. Cell. Neurosci., 11 September 2017Sec. Cellular Neurophysiology Volume - 2017 | https://doi.org/10.3389/fncel.2017.00273