A5051960429- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Sphingolipid Metabolism and Signaling
- Neurological Disorders and Treatments
- Adenosine and Purinergic Signaling
- Traumatic Brain Injury and Neurovascular Disturbances
- Phosphodiesterase function and regulation
- Graphene and Nanomaterials Applications
- Cholinesterase and Neurodegenerative Diseases
- Nanoparticles: synthesis and applications
- Nicotinic Acetylcholine Receptors Study
- Ocular Diseases and Behçet’s Syndrome
- Microplastics and Plastic Pollution
- Heme Oxygenase-1 and Carbon Monoxide
- Ion channel regulation and function
- Liquid Crystal Research Advancements
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Lipid Membrane Structure and Behavior
- Epilepsy research and treatment
Hallym University
2022-2025
Hallym Polytechnic University
2023-2024
Ischemic stroke is caused by insufficient blood flow to the brain. Astrocytes have a role in bidirectionally converting pyruvate, generated via glycolysis, into lactate and then supplying it neurons through astrocyte–neuron shuttle (ANLS). Pyruvate kinase M2 (PKM2) an enzyme that dephosphorylates phosphoenolpyruvate pyruvate during glycolysis astrocytes. We hypothesized reduction supply astrocyte PKM2 gene deletion exacerbates neuronal death. Mice harboring were established administering...
Epilepsy, a complex neurological disorder, is characterized by recurrent seizures caused aberrant electrical activity in the brain. Central to this study role of lysosomal dysfunction epilepsy, which can lead accumulation toxic substrates and impaired autophagy neurons. Our focus on phosphodiesterase-4 (PDE4), an enzyme that plays crucial regulating intracellular cyclic adenosine monophosphate (cAMP) levels converting it into (AMP). In pathological states, including increased PDE4...
Brain ischemia, a condition in which the brain is deprived of blood flow, can lead to stroke due blocked or unstable vessels. Global cerebral ischemia (GCI), characterized by an interruption deprives oxygen and nutrients, producing reactive species (ROS) that trigger cell death, kills nerve cells. Microplastics (MPs), tiny environmental pollutants, enter human body through contaminated food, water, disposable items, cosmetics, more. Once brain, MPs increase neuroinflammation overstimulating...
Traumatic brain injury (TBI) is a major health concern, often resulting in significant damage and functional impairments. A key contributing factor to TBI-induced neuronal the overactivation of AMPA glutamate receptors, leading an increased influx calcium zinc ions. This study investigates neuroprotective potential l-theanine, known for its antioxidant ability enhance glutathione synthesis, against hippocampal TBI rat model. Rats subjected TBIs were treated with two dosages l-theanine (100...
Epilepsy, a chronic neurological disorder, is triggered by various insults, including traumatic brain injury and stroke. Acid sphingomyelinase (ASMase), an enzyme that hydrolyzes sphingomyelin into ceramides, implicated in oxidative stress, neuroinflammation, neuronal apoptosis. Ceramides, which have pro-apoptotic properties, contribute to damage lysosomal dysfunction, exacerbating injury. This study investigates the role of ASMase epilepsy, hypothesizing seizure activity upregulates ASMase,...
Epilepsy, marked by abnormal and excessive brain neuronal activity, is linked to the activation of L-type voltage-gated calcium channels (LTCCs) in membranes. LTCCs facilitate entry (Ca2+) other metal ions, such as zinc (Zn2+) magnesium (Mg2+), into cytosol. This Ca2+ influx at presynaptic terminal triggers release Zn2+ glutamate postsynaptic terminal. then transported neuron via LTCCs. The resulting accumulation neurons significantly increases expression nicotinamide adenine dinucleotide...
Traumatic brain injury (TBI) broadly degrades the normal function of after a bump, blow, or jolt to head. TBI leads aggravation pre-existing dysfunction and promotes neurotoxic cascades that involve processes such as oxidative stress, loss dendritic arborization, zinc accumulation. Acid sphingomyelinase (ASMase) is an enzyme hydrolyzes sphingomyelin ceramide in cells. Under conditions, plays important role various physiological functions, differentiation apoptosis. However, under...
<title>Abstract</title> Epilepsy is a neurological disorder characterized by recurrent seizures resulting from abnormal electrical activity in the brain. During acute diseases, defective lysosomal functioning can lead to accumulation of toxic substrates cellular organelles, causing impaired autophagy. Phosphodiesterase-4 (PDE4) an enzyme that regulates cyclic adenosine monophosphate (cAMP) levels breaking it down into (AMP). PDE4 also influences function and release pro-inflammatory...