A5114613257- Growth Hormone and Insulin-like Growth Factors
- Cancer, Hypoxia, and Metabolism
- Protein Tyrosine Phosphatases
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Ovarian cancer diagnosis and treatment
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
University of Michigan
2024-2025
Michigan United
2024
<p>Supp Figure 5</p>
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<p>Verification of cell lines employed in this manuscript.</p>
<p>Supplementary Figure Legends</p>
<div>Abstract<p>Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate metastasize. Previous work identified mutational hotspots within <i>PPP2R1A</i>, which encodes Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous <i>PPP2R1A</i> mutations, P179R S256F, occur...
<p>Supp Figure 10</p>
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<p>Raw data of the PCA analysis from Broad Institute Cell Line Encyclopedia</p>
<p>table of key resources and reagents used in this manuscript.</p>
<p>Supp Figure 9</p>
<p>Supp Figure 1</p>
<p>Vector map for the EGFP overexpression (OE) plasmid</p>
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<p>Supp Figure 12</p>
<p>Vector map for the B56-alpha overexpression (OE) plasmid</p>
<p>Patient IDs used for all TCGA analysis in this manuscript</p>
<p>Supp Figure 6</p>
<p>Supp Figure 2</p>
Abstract The use of immunodeficient mice for human tumor engraftment has proven to be an essential model cancer, with uses ranging from basic science translational research. However, low rates, slow growth, and smaller volumes can limitations. Previously, we reported a highly rat strain developed by Hera BioLabs, the functional deletion both Rag2 Il2rg genes on Sprague-Dawley background (SRG RAT®), which lacks B, T, NK cells. We have shown that SRG supports growth multiple PDX CDX models,...
Abstract Uterine cancer is the only type for which survival has fallen in past four decades. This year United States, over 13,000 women will die from this disease, surpassing ovarian first time: making uterine deadliest gynecological cancer. Mortality primarily due to aggressive, non-endometrioid subtypes of disease include serous carcinomas and carcinosarcomas (high-grade subtypes). Molecularly, high-grade tumors harbor few mutations, however, almost every tumor harbors a Tp53 mutation,...
Abstract Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically equipped to disseminate metastasize. Previous work identified mutational hotspots within PPP2R1A, which encodes Aα scaffolding subunit of protein phosphatase 2A (PP2A), a heterotrimeric serine/threonine phosphatase. Two recurrent heterozygous PPP2R1A mutations, P179R S256F, occur exclusively high-grade subtypes cancer can drive...