A5075838399- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ethics in Clinical Research
- Mitochondrial Function and Pathology
- Prenatal Screening and Diagnostics
- Patient-Provider Communication in Healthcare
- Peroxisome Proliferator-Activated Receptors
- CRISPR and Genetic Engineering
- Autism Spectrum Disorder Research
- Coenzyme Q10 studies and effects
- Biomedical Ethics and Regulation
- Gynecological conditions and treatments
- Cancer Genomics and Diagnostics
- Family Support in Illness
- Respiratory Support and Mechanisms
- Biomedical and Engineering Education
- Neuroscience of respiration and sleep
- Health Systems, Economic Evaluations, Quality of Life
- RNA regulation and disease
- Uterine Myomas and Treatments
- Heat shock proteins research
- Global Cancer Incidence and Screening
- Adipose Tissue and Metabolism
- ATP Synthase and ATPases Research
- Reproductive Health and Contraception
- Viral Infectious Diseases and Gene Expression in Insects
Mayo Clinic in Florida
2023-2025
Mayo Clinic
2022-2025
WinnMed
2022-2025
University of Minnesota System
2020
Despite considerable scientific progress and the evolution of regulatory pathways to ensure safety efficacy, US healthcare continues see increasing health disparities. This suggests that clinical translation in itself cannot be only measure its own success, especially when most marginalized patients, are neglected development implementation medical innovations. raises question whether a system is narrowly focused on technical achievement can meet moral obligations medicine public health. We...
Psychological safety is critical to early and continued engagement with healthcare providers, yet no studies have explored this concept in relationship cancer care. Black/African American ("Black") individuals experience disparities breast ovarian beyond what can be explained biologically. We factors influencing psychological among Black patients their family members. Socioeconomically diverse a personal diagnosis or history of and/or were invited complete semi-structured qualitative...
Abstract Objectives Thirty‐five states, including Florida, now cover cell‐free DNA (cfDNA) screening of fetuses for all pregnant patients enrolled in state public insurance programs. We interviewed Black and Hispanic obstetric at a safety net clinic Florida shortly after the rolled out cfDNA as first‐tier method publicly insured patients. Methods receiving prenatal care from or maternal fetal medicine federally qualified health center Jacksonville, FL were invited to participate qualitative...
Abstract Background Uterine fibroids are non-cancerous neoplasms that arise from the uterus affecting over 75% of women. However, there is a disparity with Black women having an increased prevalence nearly 80%. also experience symptom burden, including younger age at time diagnosis and number volume fibroids. Less known about other ethnoracially diverse such as Latinas potential cultural impacts on fibroid burden treatment. Methods Community engagement studios were conducted to facilitate...
Airway inflammation and pro-inflammatory cytokines such as tumor necrosis factor alpha (TNFα) underlie the pathophysiology of respiratory diseases, including asthma. Previously, we showed that TNFα activates inositol-requiring enzyme 1α (IRE1α)/X-box binding protein 1 spliced (XBP1s) endoplasmic reticulum (ER) stress pathway in human airway smooth muscle (hASM) cells. The ER is activated by accumulation unfolded proteins ER. Accordingly, chemical chaperones 4-phenylbutyric acid (4-PBA) may...
Cellular mitochondrial function can be assessed using high-resolution respirometry that measures the O2 consumption rate (OCR) across a number of cells. However, direct measurement cellular provides valuable information and physiological insight. In present study, we used quantitative histochemical technique to measure activity succinate dehydrogenase (SDH), key enzyme located in inner membrane, which participates both tricarboxylic acid (TCA) cycle electron transport chain (ETC) as Complex...
Inflammation triggers a homeostatic response that is mediated by pro‐inflammatory cytokines such as TNFα. We hypothesize in motor neuron‐like cell line, NSC‐34, TNFα decreases mitochondrial function, specifically succinate dehydrogenase (SDH) activity, which key enzyme the tricarboxylic acid (TCA) cycle well complex II electron transport chain (ETC). Experiments were performed on cultured NSC‐34 cells differentiated serum depletion until neurite structures (>50 μm) observed. The treated...
Previously, we reported that airway inflammation mediated by pro-inflammatory cytokines such as TNFα induces hypercontractility and increased ATP consumption in human smooth muscle (hASM). We also found an increase maximum O2 rate well mitochondrial biogenesis volume density. However, when normalized to volume, per mitochondrion is reduced hASM after exposure. Unfortunately, standard respirometry (e.g., Seahorse) measures only the averaged of a large number cells. In present study, used...
Cellular mitochondrial function can be assessed using high resolution respirometry that measures O2 consumption rate during various conditions systematically alter the tricarboxylic acid (TCA) cycle or electron transport chain (ETC). However, current does not measure at single cell level, but actually average across a number of cells (either isolated in tissues). Thus, assumes physiological homogeneity cells. many tissues, varies and this heterogeneity is physiologically important....