A5004235964- Gout, Hyperuricemia, Uric Acid
- Cardiac Imaging and Diagnostics
- Pharmacological Effects of Natural Compounds
- Atrial Fibrillation Management and Outcomes
- Inflammasome and immune disorders
- Kidney Stones and Urolithiasis Treatments
- Spondyloarthritis Studies and Treatments
- Coronary Interventions and Diagnostics
- Case Reports on Hematomas
- Pancreatitis Pathology and Treatment
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- S100 Proteins and Annexins
- Advanced Glycation End Products research
- Ginseng Biological Effects and Applications
- Blood Pressure and Hypertension Studies
- Silymarin and Mushroom Poisoning
Central South University
2024-2025
Second Xiangya Hospital of Central South University
2024-2025
Hunan Provincial Center for Disease Control and Prevention
2025
Shanghai University of Traditional Chinese Medicine
2022-2025
Shuguang Hospital
2022-2025
Abstract Background Atrial fibrillation and atrial flutter (AF/AFL) are critical global health concerns, yet studies on burden trends sex differences remain limited. Method This study utilized data from the Global Burden of Disease 2021 study, applying methods such as age-period-cohort analysis joinpoint regression models to evaluate in incidence, prevalence, mortality, disability-adjusted life years (DALYs) AF/AFL among individuals aged 30 above 1990 2021, employed Bayesian (BAPC) predict...
Traditional Chinese Medicine (TCM) Compound Shizhifang (SZF), consisting of the seeds four herbs, has been used in Shanghai Shuguang Hospital China for more than 20 years and proven its clinical safety efficacy lowering uric acid protecting kidney function. Hyperuricemia (HUA)-induced pyroptosis renal tubular epithelial cells serves as a significant cause damage. SZF proves to be effective alleviating injury inflammation infiltration HUA. However, inhibiting effect on HUA still remains...
This study aimed to explore the main chemical components of Jiangniaosuan Formula (JNSF), therapeutic effect JNSF on hyperuricemia (HUA) mice, and underlying mechanism by which inhibits renal tubular epithelial cell apoptosis. Ultra Performance Liquid Chromatography-Quadrupole-Time Flight Mass Spectrometry (UPLC-Q-TOF-MS) was used analyze composition its serum metabolites. Network pharmacology performed predict potential target genes pathways. In vitro in vivo models were established verify...
Sepsis-induced atrial fibrillation (AF) is driven by systemic inflammation and macrophage-mediated remodeling, with proinflammatory M1 macrophages playing a key role. This study investigates whether GTS-21, an α7nAChR agonist, can reduce AF susceptibility promoting macrophage polarization towards the anti-inflammatory M2 phenotype. A mouse model of lipopolysaccharide (LPS) (10 mg/kg)-induced sepsis was used to explore relationship between AF. GTS-21 (20 mg/kg) administered assess its impact...
Abstract Background Guidelines on coronary intermediate lesions strongly recommend deferred revascularization after detecting a normal fractional flow reserve (FFR). Researches about triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) cardiovascular diseases has also been well conducted. However, the association of TG/HDL-C and long-term adverse clinical outcomes remains unknown for patients following FFR. Methods This study retrospectively included 374 artery disease (CAD) with...
Endothelial injury and inflammation are the main pathological changes in hyperuricemic nephropathy (HN); however, they have not been assessed patients early, middle, late phases of HN.To investigate endothelial inflammatory conditions between with HN at chronic kidney disease (CKD) stages 3-4 CKD 1-2.This study enrolled 80 (49 31 stage 1-2 3-4, respectively) from Department Nephrology, Shuguang Hospital Affiliated to Shanghai University Traditional Chinese Medicine July 2021 January 2022....
Ethnopharmacological relevanceShizhifang Decoction, a traditional Chinese medicine prescription formulated by Professor Zheng Pingdong of Shuguang Hospital, has been widely utilized in clinical settings for the treatment hyperuricemia due to its proven safety and efficacy.ObjectiveIn this study, we used network pharmacology, molecular docking technology, experimental validation elucidate therapeutic effects underlying mechanisms Shizhifang Decoction managing hyperuricemia.MethodsQuality...
Background and Aims The role of fractional flow reserve (FFR) in coronary intermediate lesions has been widely recommended by guidelines. effect uric acid (UA) on cardiovascular events is also well known. However, the relationship between UA long-term outcomes patients who received FFR with remains unknown. Methods Results We retrospectively included 428 underwent both angiography (CAG) FFR. Participants were stratified into two groups based median UA. primary endpoint was composite major...
Hyperuricemic nephropathy is a highly prevalent kidney disease induced by excessive accumulation and deposition of monosodium urate in kidney, which contributes to the loss function. The Jiangniaosuan formulation (JNSF) Chinese herbal medicine treatment. aim this study evaluate its efficacy safety among patients with hyperuricemic at chronic (CKD) stages 3-4 obstruction phlegm turbidity blood stasis syndrome.Our research designed as single-centre, double-blinded, randomized,...