A5100451499- Prostate Cancer Treatment and Research
- Esophageal Cancer Research and Treatment
- Bone health and treatments
- Gastric Cancer Management and Outcomes
- Mesenchymal stem cell research
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Esophageal and GI Pathology
- TGF-β signaling in diseases
- Tissue Engineering and Regenerative Medicine
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Bone Metabolism and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Spectroscopy and Chemometric Analyses
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Plant Pathogens and Fungal Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Electrospun Nanofibers in Biomedical Applications
Chinese Academy of Sciences
2002-2025
Kunming Institute of Zoology
2021-2025
Center for Life Sciences
2025
Peking University
2016-2025
Shenzhen Second People's Hospital
2024-2025
Shenzhen University
2025
University of Toledo
2021-2024
The First People's Hospital of Shunde
2020-2024
Zigong First People's Hospital
2018-2024
University of Science and Technology of China
2021-2024
Axillary lymph node metastasis (ALNM) status, typically estimated using an invasive procedure with a high false-negative rate, strongly affects the prognosis of recurrence in breast cancer. However, preoperative noninvasive tools to accurately predict ALNM status and disease-free survival (DFS) are lacking.To develop validate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) radiomic signatures for identification assess individual DFS patients early-stage cancer.This...
in current clinical practice, the standard evaluation for axillary lymph node (ALN) status breast cancer has a low efficiency and is based on an invasive procedure that causes operative-associated complications many patients. Therefore, we aimed to use machine learning techniques develop efficient preoperative magnetic resonance imaging (MRI) radiomics approach of ALN explore association between tumor microenvironment patients with early-stage cancer.in this retrospective multicenter study,...
The Coronavirus Disease 2019 (COVID-19) pandemic has been a great threat to global public health since 2020. Although the advance on vaccine development largely achieved, strategy alleviate immune overactivation in severe COVID-19 patients is still needed. NLRP3 inflammasome activated upon SARS-CoV-2 infection and associated with severity. However, processes by which involved disease remain unclear.We infected THP-1 derived macrophages, knockout mice, human ACE2 transgenic mice live...
Background Somatic genetic CDKN2A, TP53, and DNA content abnormalities are common in many human cancers their precursors, including esophageal adenocarcinoma (EA) Barrett's esophagus (BE), conditions for which aspirin other nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as possible chemopreventive agents; however, little is known about the ability of a biomarker panel to predict progression cancer nor how NSAID use may modulate progression. We aimed evaluate somatic with...
Abstract There is debate in the literature over relative importance of genetic instability and clonal expansion during progression to cancer. Barrett’s esophagus a uniquely suited model investigate neoplastic prospectively because periodic endoscopic biopsy surveillance recommended for early detection esophageal adenocarcinoma. We hypothesized that clones with would predict measured p16 (CDKN2A/INK4A) lesions (loss heterozygosity, mutations, CpG island methylation), p53 (TP53) mutation)...
Neoplastic progression is an evolutionary process driven by the generation of clonal diversity and natural selection on that within a neoplasm. We hypothesized associated with risk to cancer. obtained molecular data from cohort 239 participants Barrett's esophagus, including microsatellite shifts loss heterozygosity, DNA content tetraploidy aneuploidy, methylation, sequence mutations. Using these data, we tested all major measurement methods, genetic divergence entropy-based measures,...
Abstract Communication between cancer cells and the tumor microenvironment results in modulation of complex signaling networks that facilitate progression. Here, we describe a new mechanism intercellular communication originating from large oncosomes (LO), which are cell–derived, atypically (1–10 μm) extracellular vesicles (EV). We demonstrate that, context prostate cancer, LO harbor sustained AKT1 kinase activity, nominating them as active platforms. Active was detected circulating EV...
All cancers are believed to arise by dynamic, stochastic somatic genomic evolution with genome instability, generation of diversity, and selection alterations that underlie multistage progression cancer. Advanced esophageal adenocarcinomas have high levels copy number alterations. Barrett's esophagus is a risk factor for developing adenocarcinoma, chromosomal (SCA) known occur in esophagus. The vast majority (∼95%) individuals do not progress adenocarcinoma during their lifetimes, but small...
The extracellular signal-regulated kinases (ERK1 and 2) are widely-expressed they modulate proliferation, survival, differentiation, protein synthesis in multiple cell lineages. Altered ERK1/2 signaling is found several genetic diseases with skeletal phenotypes, including Noonan syndrome, Neurofibromatosis type 1, Cardio-facio-cutaneous suggesting that MEK-ERK signals regulate human development. Here, we examine the consequence of Erk1 Erk2 disruption functions osteoclasts, specialized...
Background: Perineural invasion (PNI) of intrahepatic cholangiocarcinoma (ICC) is a strong independent risk factor for tumor recurrence and long-term patient survival. However, there lack non-invasive tools accurately predicting the PNI status. We develop validate combined model incorporating radiomics signature clinicoradiological features based on machine learning in ICC, used Shapley Additive explanation (SHAP) to visualize prediction process clinical application. Methods: This...
Mercury chloride can cause severe liver injury, which involves multiple mechanisms. Ferroptosis plays an important role in regulating the development and progression of pathology. Oleanolic acid (OA), a triterpenoid compound widely exists fruits, has protective properties. In this study, we investigated ferroptosis mercury chloride-induced injury intervention effect OA, clarified potential mechanism. We found that oxidative stress tissues cells, leading to lipid peroxidation iron overload,...
One critical mechanism through which prostate cancer (PCa) adapts to treatments targeting androgen receptor (AR) signaling is the emergence of ligand-binding domain-truncated and constitutively active AR splice variants, particularly AR-V7. While AR-V7 has been intensively studied, its ability activate distinct biological functions compared with full-length (AR-FL), role in regulating metastatic progression castration-resistant PCa (CRPC), remain unclear. Our study found that, under...