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Ajay Sudan

ORCID: 0009-0004-8624-8732
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A5026264981
Research Areas
  • Colorectal Cancer Treatments and Studies
  • Radiomics and Machine Learning in Medical Imaging
  • Cancer Treatment and Pharmacology
  • Medical Imaging Techniques and Applications
  • Pharmacological Effects and Toxicity Studies
  • Epilepsy research and treatment
  • Lung Cancer Treatments and Mutations
  • Metabolism and Genetic Disorders
  • Neonatal and fetal brain pathology
  • Gastric Cancer Management and Outcomes
  • Boron Compounds in Chemistry

Newcastle upon Tyne Hospitals NHS Foundation Trust
 2023

St James's University Hospital
 2023

Wellcome Trust
 2023

Royal Manchester Children's Hospital
 2013-2019

 Supplementary Figure S3 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Scatterplot: AREG vs EREG</p>

10.1158/1078-0432.27032536 preprint EN 2024-09-16
 Supplementary Figure S1 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Example AREG and EREG immunohistochemistry</p>

10.1158/1078-0432.27032542 preprint EN 2024-09-16
 Supplementary Methods S1 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Supplementary methods</p>

10.1158/1078-0432.27032533 preprint EN 2024-09-16
 Supplementary Figure S3 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Scatterplot: AREG vs EREG</p>

10.1158/1078-0432.27032536.v1 preprint EN 2024-09-16
 Supplementary Figure S1 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Example AREG and EREG immunohistochemistry</p>

10.1158/1078-0432.27032542.v1 preprint EN 2024-09-16
 Supplementary Figure S2 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Study flow diagram</p>

10.1158/1078-0432.27032539.v1 preprint DA 2024-09-16
 Supplementary Methods S1 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Supplementary methods</p>

10.1158/1078-0432.27032533.v1 preprint EN 2024-09-16
 Supplementary Figure S2 from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Study flow diagram</p>

10.1158/1078-0432.27032539 preprint DA 2024-09-16
 Data from Associations between AI-assisted tumor amphiregulin and epiregulin IHC and outcomes from anti-EGFR therapy in the routine management of metastatic colorectal cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<div>Abstract<p>Purpose: High tumor production of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG), predicted benefit from anti-EGFR therapy for metastatic colorectal cancer (mCRC) in a retrospective analysis clinical trial data. Here, AREG/EREG immunohistochemistry (IHC) was analyzed cohort patients who received as part routine care, including key contexts not investigated previous analysis. Experimental Design: Patients panitumumab or cetuximab ± chemotherapy...

10.1158/1078-0432.c.6740543.v3 preprint EN 2024-09-16
 Supplementary Figure S1 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Example AREG and EREG immunohistochemistry</p>

10.1158/1078-0432.23676026.v1 preprint EN cc-by 2023-07-13
 Supplementary Methods S1 from Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer
OPENALEX - Publications 
Christopher J.M. Williams Faye Elliott Nancy Sapanara Faranak Aghaei Liping Zhang and 49 more Andrea Murányi Dongyao Yan Isaac Bai Zuo Zhao Michael Shires Henry M. Wood Susan D. Richman Gemma Hemmings Michael Hale Daniel Bottomley Leanne Galvin Caroline Cartlidge Sarah Dance Chris M. Bacon Laura Mansfield Kathe Young-Zvandasara Ajay Sudan Katy Lambert Irena Bibby Sarah E. Coupland Amir Montazeri Natalie Kipling Kathryn Hughes Simon S. Cross Alice Dewdney Leanne Pheasey Cathryn Leng Tatenda Gochera D. Chas Mangham Mark Saunders Martin Pritchard Helen Stott Abhik Mukherjee Mohammad Ilyas Rafael Silverman Georgina Hyland Declan Sculthorpe Kirsty Thornton I.M. Gould Ann O’Callaghan Nicholas Brown Samantha Turnbull Lisa Shaw Michel Seymour Nicholas P. West Jenny F. Seligmann Shalini Singh Kandavel Shanmugam Philip Quirke

<p>Supplementary methods</p>

10.1158/1078-0432.23676014 preprint EN cc-by 2023-07-13
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