A5085955560- Protease and Inhibitor Mechanisms
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Circular RNAs in diseases
- Cancer Research and Treatments
Zhejiang University
2025
Anhui Medical University
2024
First Affiliated Hospital of Anhui Medical University
2024
Peking University First Hospital
2006
Peking University
2006
MiR-146b has been identified as being overexpressed in human bladder cancer (BCa) and implicated promoting cell invasion. However, its specific involvement BCa growth remains unclear. In this study, we demonstrate that the downregulation of miR-146b significantly suppresses tumorigenic cells both vitro vivo by inducing G0/G1 cycle arrest. Specifically, inhibition resulted a significant reduction colony formation (p < 0.05) anchorage-independent UMUC3 T24T cells, measured soft agar assays,...
Abstract Background Osteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) degradation. Charged multivesicular body protein 5 (CHMP5), a member of body, has been reported to serve as an anti-apoptotic participate in leukemia development. However, effects CHMP5 on ECM degradation OA remain unclear. Methods In this study, quantitative proteomics was performed analyze differential proteins between normal patient articular...