A5040391095- Pelvic and Acetabular Injuries
- Simulation-Based Education in Healthcare
- Trauma and Emergency Care Studies
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Bone and Joint Diseases
- Antimicrobial Peptides and Activities
- Bone fractures and treatments
- Nicotinic Acetylcholine Receptors Study
Nanjing Medical University
2021-2025
Jiangsu Province Hospital
2021-2025
Osteoarthritis (OA) is the most common chronic joint disease in elderly population. Growing evidence indicates that a balance between autophagy and apoptosis chondrocytes plays key role OA's cartilage degradation. Thus, drugs targeting are potential therapeutic approaches for OA treatment. In previous studies, we found activation of α7 nicotinic acetylcholine receptors (α7-nAChRs) alleviated monosodium iodoacetate (MIA)-induced degradation osteoarthritis pain. To explore functions α7-nAChRs...
Background Teaching severe pelvic trauma poses a significant challenge in orthopedic surgery education due to the necessity of both clinical reasoning and procedural operational skills for mastery. Traditional methods instruction, including theoretical teaching mannequin practice, face limitations complexity, unpredictability treatment scenarios, scarcity typical cases, abstract nature traditional teaching, all which impede students’ knowledge acquisition. Objective This study aims introduce...
Abstract Infection after fracture fixation (IAFF), a complex infectious disease, causes inflammatory destruction of bone tissue and poses significant clinical challenge. miR-345-3p is biomarker for tibial infected nonunion; however, the comprehensive mechanistic role in IAFF elusive. In this study, we investigated pathogenesis through vivo vitro experiments. vivo, rat model IAFF, expression was downregulated, accompanied by increased M1 macrophage infiltration secretion proinflammatory...
<sec> <title>BACKGROUND</title> Teaching severe pelvic trauma poses a significant challenge in orthopedic surgery education due to the necessity of both clinical reasoning and procedural operational skills for mastery. Traditional methods instruction, including theoretical teaching mannequin practice, face limitations complexity, unpredictability treatment scenarios, scarcity typical cases, abstract nature traditional teaching, all which impede students’ knowledge acquisition. </sec>...