A5100317926- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Metal complexes synthesis and properties
- Radiopharmaceutical Chemistry and Applications
- Protein purification and stability
- Lymphoma Diagnosis and Treatment
- Magnetism in coordination complexes
- Pesticide and Herbicide Environmental Studies
- Weed Control and Herbicide Applications
- Nuclear Structure and Function
- Polymer-Based Agricultural Enhancements
- Advanced Biosensing Techniques and Applications
- RNA Research and Splicing
- Biosimilars and Bioanalytical Methods
- Supramolecular Chemistry and Complexes
- Transportation and Mobility Innovations
- Human Mobility and Location-Based Analysis
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Biopolymer Synthesis and Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Organic Chemistry Cycloaddition Reactions
- Synthesis of Organic Compounds
- Polyamine Metabolism and Applications
Dalian University of Technology
2012-2025
Fudan University Shanghai Cancer Center
2025
Shanghai Medical College of Fudan University
2025
Shanghai Cancer Institute
2025
Dalian University
2012-2024
University of Bern
2016
National Natural Science Foundation of China
2005
Nankai University
2001-2002
Abstract Apoptosis is the most common form of neutrophil death under both physiological and inflammatory conditions. However, forms nonapoptotic have also been observed. In current study, we report that human neutrophils undergo necroptosis after exposure to GM-CSF followed by ligation adhesion receptors such as CD44, CD11b, CD18, or CD15. Using a pharmacological approach, demonstrate presence receptor-interacting protein kinase-3 (RIPK3)—a mixed lineage kinase–like (MLKL) signaling pathway...
The dysregulation of polyamines in tumors has made polyamine metabolism an appealing target for cancer therapy. Gene mutations drive the reprogramming tumors, presenting promising opportunities clinical treatment. proposed strategies involve inhibiting biosynthesis while also targeting transport system as antitumor approaches. A growing number drugs aimed at and systems are undergoing trials. Polyamine plays a role regulating signaling pathways, suggesting potential combination therapies...
This study examines the roles of Cyclin B1 (CCNB1), Polo-Like Kinase 1 (PLK1), and Heparanase (HPSE) in breast cancer progression using a multi-omics approach. These genes are known for their involvement various cancer-related processes, but precise contributions to remain unclear. We employed an integrative analysis combining transcriptomics, proteomics, DNA methylation profiling, immune infiltration analysis, single-cell RNA sequencing investigate expression patterns, regulatory...
The syntheses, characterization, crystal structures, and photophysical electrochemical properties of two dinuclear polymeric Ag(I) complexes with three polypyridyl ligands, 2,3-di-2-pyridylquinoxaline (L(1)), 2,3-di-2-pyridyl-5,8-dimethoxyquinoxaline (L(2)), 2,3,7,8-tetrakis(2-pyridyl)pyrazino[2,3-g] quinoxaline (L(3)), are described. structures the boxlike L(1) L(2) chemically same but differently crystallized one-dimensional zigzag chain coordination polymers also consisting subunits have...
Background Checkpoint targets play a key role in tumor-mediated immune escape and therefore are critical for cancer immunotherapy. Unfortunately, there is lack of bioinformatics resource that compile all the checkpoint translational research drug discovery immuno-oncology. Methods To this end, we developed therapeutic target database (CKTTD), first comprehensive (proteins, miRNAs LncRNAs) their modulators. A scoring system was adopted to filter more relevant with high confidence. In...
CRM1 (chromosomal region maintenance 1, also referred to as exportin 1 or XPO1) plays a crucial role in maintaining the appropriate nuclear levels of tumor suppressor proteins (TSPs), growth regulatory (GRPs), and antiapoptotic proteins, thereby contributing significantly their anticancer effects. Dysregulation CRM1-mediated transport, observed range cancers such colon cancer well autoimmune diseases, highlights its significance various disease processes. In this paper, we employed...
Background: The overactivation of NF-κB signaling is a key hallmark for the pathogenesis extranodal natural killer/T cell lymphoma (ENKTL), very aggressive subtype non-Hodgkin’s yet with rather limited control strategies. Previously, we found that dysregulated exportin-1 (also known as CRM1) mainly responsible tumor cells to evade apoptosis and promote tumor-associated pathways such signaling. Methods: Herein reported discovery biological evaluation potent small molecule CRM1 inhibitor,...
A significant challenge in vehicular networks is to efficiently provide multimedia services with the constraints of limited resources, high mobility, opportunistic contact, and service time requirements. In order guarantee vehicle user satisfaction service, proliferation distributed peer-to-peer (P2P) cooperative transmission technologies, P2P-based VANET has recently received a substantial amount interest. Using P2P thought at same time, set methods should be designed avoid disadvantage...
The title complex, (acetonitrile)(6,7-dicyanodipyrido[3,2-f;2,3-h]quinoxine)dinitrocobalt(II), [Co(NO3)2(C2H3N)(C16H6N6)], crystallizes in the monoclinic system with space group P21. CoII center is heptacoordinated by two N atoms of pyridine moieties, four O nitrate anions and one atom a CH3CN molecule. crystal structure reveals that CoN3O4 coordination sphere has distorted pentagonal-bipyramid geometry.
The reaction of 7α-acetyl-6,14-endoethano-6,7,8,14-tetrahydrothebaine with 2-(thien-2-yl)ethylmagnesium bromide was investigated. tertiary alcohol derivative 7α-[R-1-hydroxyl-1-methyl-3-(thien-2-yl)propyl])-6,14-endoethano-6,7,8,14-tetrahydrothebaine (3) and a by-product 4 were isolated. structure elucidated by X-ray analysis. Grignard shows high degree stereoselectivity according Cram rule. crystal indicates that dihydrofuran ring opened to form phenolic hydroxyl group three-membered...
<p>Analysis of purified BiJ591 by SEC-HPLC</p>
<p>PSMA and CD3 expression of targeted cells</p>
<p>BiJ591 solution composition before spray-drying</p>
<p>Copolymers composition details</p>
<p>BiJ591 plasma concentrations measured in BALB/c mice during pK assay</p>
<p>Mean pharmacokinetics parameters of BiJ591</p>
<p>BiJ591 solution composition before spray-drying</p>