A5011329367- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hormonal Regulation and Hypertension
- Reproductive System and Pregnancy
- Renin-Angiotensin System Studies
- Gestational Diabetes Research and Management
- Blood Pressure and Hypertension Studies
- Lipoproteins and Cardiovascular Health
- COVID-19 Clinical Research Studies
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- MicroRNA in disease regulation
- Nitric Oxide and Endothelin Effects
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Disease and Adiposity
- Prenatal Screening and Diagnostics
- Receptor Mechanisms and Signaling
- Biomarkers in Disease Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Ultrasound in Clinical Applications
- Apelin-related biomedical research
- Body Composition Measurement Techniques
Erasmus MC
2015-2025
Erasmus University Rotterdam
2014-2024
Center for Vascular Biology Research
2023
Ikazia Ziekenhuis
2017-2019
Maasstad Ziekenhuis
2017
Decision Sciences (United States)
2017
Reinier de Graaf Hospital
2017
Rotterdam University of Applied Sciences
2012
Goethe University Frankfurt
2012
Institute on Aging
2012
Vascular dysfunction in atherosclerosis and diabetes mellitus, as observed the aging population of developed societies, is associated with vascular DNA damage cell senescence. We hypothesized that cumulative during contributes to dysfunction.In mice genomic instability resulting from defective nucleotide excision repair genes ERCC1 XPD (Ercc1(d/-) Xpd(TTD) mice), we explored age-dependent function compared wild-type mice. Ercc1(d/-) showed increased senescence, accelerated development...
Women with preeclampsia display low renin-angiotensin-aldosterone system activity and a high antiangiogenic state, the latter characterized by levels of soluble Fms-like tyrosine kinase (sFlt)-1 reduced placental growth factor levels. To investigate whether suppression in is because this disturbed angiogenic balance, we measured mean arterial pressure, creatinine, endothelin-1 (ET-1), components pregnant women (≥85; n=38) or (<85; n=65) kinase-1/placental ratio. Plasma ET-1 were increased...
Chemerin, an inflammatory adipokine, is upregulated in preeclampsia, and its placental overexpression results preeclampsia-like symptoms mice. Statins may lower chemerin.
To investigate the stability throughout day of protein to creatinine ratio (PCR) in spot urine, demonstrate whether PCR is a valid alternative for 24-hour investigation pregnant women.Prospective study.Tertiary referral university centre.Women suspected having pre-eclampsia, admitted Erasmus Medical Centre.Twenty-four-hour urine collections and simultaneously three single voided 5-ml aliquots were obtained at 8 a.m., 12 a.m. (noon) 5 p.m. A was measured each specimen compared with...
Maternal circulating levels of the adipokine chemerin are elevated in preeclampsia, but its origin and contribution to preeclampsia remain unknown. We therefore studied (1) placental expression release human pregnancy, (2) consequences overexpression via lentivirus-mediated trophoblast-specific gene manipulation both mice immortalized trophoblasts. Placental were increased women with their correlated positively soluble Fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio,...
Angiotensin II type 2 (AT(2)) receptor stimulation has been linked to vasodilation. Yet, AT(2) receptor-independent hypertension and hypotension (or no effect on blood pressure) have observed in vivo after application of the agonist compound 21 (C21). We, therefore, studied its effects vitro, using preparations known display receptor-mediated responses. Hearts Wistar rats, spontaneously hypertensive rats (SHRs), C57Bl/6 mice, knockout mice were perfused according Langendorff. Mesenteric...
To assess the incremental value of a single determination serum levels sFlt-1 (soluble Fms-like tyrosine kinase 1) and PlGF (placental growth factor) or their ratio, without using cutoff values, for prediction maternal fetal/neonatal complications pregnancy prolongation, 620 women with suspected/confirmed preeclampsia, aged 18 to 48 years, were included in prospective, multicenter, observational cohort study. Women had singleton pregnancies median duration 34 (range, 20-41) weeks....
To assess the evolution of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) ratio in women with suspected or confirmed pre-eclampsia (PE), and investigate changes sFlt-1 PlGF levels pre-eclamptic after delivery.This was an exploratory study which secondary analysis performed on a prospective cohort that enrolled singleton pregnancy PE from 18 weeks' gestation, carried out between December 2013 April 2016 at Department Obstetrics Erasmus Medical Center Rotterdam....
The severity of COVID-19 after SARS-CoV-2 infection is unpredictable. Angiotensin-converting enzyme-2 (ACE2) the receptor responsible for coronavirus binding, while subsequent cell entry relies on priming by serine protease TMPRSS2 (transmembrane protease, 2). Although renin-angiotensin-aldosterone-system (RAAS) blockers have been suggested to upregulate ACE2, their use in patients now considered well tolerated. aim our study was investigate parameters that determine severity, focusing...
Background We aimed to evaluate the value of inhibin A and PAPP‐A2 (pregnancy‐associated plasma protein‐A2) as novel biomarkers in prediction preeclampsia‐related complications how they compare with angiogenic biomarkers. Methods Results Making use a secondary analysis prospective, multicenter, observational study, intended usefulness sFlt‐1 (soluble Fms‐like tyrosine kinase‐1)/PlGF (placental growth factor) ratio, we measured levels 524 women suspected/confirmed preeclampsia. Women had...
The adipokine chemerin regulates adipogenesis and the metabolic function of both adipocytes liver. Chemerin is elevated in preeclamptic women, overexpression placental trophoblasts induces preeclampsia-like symptoms mice. Preeclampsia known to be accompanied by dyslipidemia, albeit via unknown mechanisms. Here, we hypothesized that might a contributor dyslipidemia.Serum lipid fractions as well lipid-related genes proteins were determined pregnant mice with chemerin-overexpressing human...
A model that can predict reliably the risk of pre-eclampsia (PE)-related pregnancy complications does not exist. The aim this study was to develop and validate internally a clinical prediction composite outcome PE-related maternal fetal within 7, 14 30 days testing in women with suspected or confirmed PE.The data for were derived from prospective, multicenter, observational cohort on singleton PE at 20 < 37 weeks' gestation. For development model, possible contribution standard laboratory...
Renin inhibitors like aliskiren not only block renin but also bind prorenin, thereby inducing a conformational change (like the induced by acid) allowing its recognition in renin-specific assay. Consequently, can be used to measure prorenin. VTP-27999 is new inhibitor with an aliskiren-like IC50 and t1/2, much higher bioavailability. This study addressed (pro)renin changes during treatment of volunteers or aliskiren. Both drugs increased immunoreactivity. Treatment plasma samples from...