A5103150291- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Catalytic Cross-Coupling Reactions
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Catalytic C–H Functionalization Methods
- Antibiotic Resistance in Bacteria
- Click Chemistry and Applications
- Pneumonia and Respiratory Infections
- Food composition and properties
- Parkinson's Disease Mechanisms and Treatments
- Biofuel production and bioconversion
- Asymmetric Hydrogenation and Catalysis
- Quinazolinone synthesis and applications
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Metal-Catalyzed Oxygenation Mechanisms
- Pharmacogenetics and Drug Metabolism
- Synthesis and Reactivity of Heterocycles
- Computational Drug Discovery Methods
- Advanced Synthetic Organic Chemistry
- Enzyme Production and Characterization
National Institute of Pharmaceutical Education and Research
2025
Institute of Management Technology
2024
National Institute of Pharmaceutical Education and Research
2020-2024
Abstract A series of pyrrole‐thiazolidin‐4‐one conjugates were synthesized and evaluated for their anti‐mycobacterial anti‐bacterial activities. Two compounds, 10 a k , the most effective produced identical MICs (0.5 μg/mL) against M. tuberculosis H37Rv with high selectivity index. Upon evaluation ESKAP bacteria panel, compound g emerged S. aureus (MIC=8.0 while o activity A. baumannii (MIC=4.0 μg/mL). molecular docking study revealed that active has similar binding interactions as those...
We introduced, for the first time, N -methoxyamide directed proximal C–H bond activation of imidazo[1,2- a ]pyridines C(sp 2 )–C(sp ) formation via transition metal catalysed approach to obtain C-5 arylated ]pyridines.
A series of novel furan-2-yl-1H-pyrazoles and their chemical precursors were synthesized evaluated for effectiveness at disrupting α-synuclein (α-syn) aggregation in vitro. The compounds found to inhibit α-syn with efficacy comparable the promising drug candidate anle138b. results this study indicate that 8b, 8l, 9f may qualify as secondary leads structure–activity relationship studies aimed identify suitable improving modulatory activity targeted self-assembly related Parkinson's disease.
We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish arylethylbenzamides excellent chemo- and regioselectivity. The reaction tolerates an extensive variety functional groups has been successfully extended electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, afford hydroamidated products. Excellent chemoselectivity was observed amide group over amine. proposed...