A5100433293- Sleep and Wakefulness Research
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Electromagnetic Fields and Biological Effects
- Regulation of Appetite and Obesity
- Retinal Development and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Restless Legs Syndrome Research
- Cell Adhesion Molecules Research
- Ion channel regulation and function
- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Total Knee Arthroplasty Outcomes
- Receptor Mechanisms and Signaling
- Neuroscience of respiration and sleep
- Orthopaedic implants and arthroplasty
- Neuropeptides and Animal Physiology
- Vasculitis and related conditions
- Platelet Disorders and Treatments
- Electron Spin Resonance Studies
- Chronic Kidney Disease and Diabetes
- Cancer, Stress, Anesthesia, and Immune Response
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Receptor Mechanisms and Effects
Army Medical University
2015-2025
Xinqiao Hospital
2016-2025
Second Hospital of Anhui Medical University
2025
Anhui Medical University
2025
Hubei University of Technology
2024
Daping Hospital
2015-2024
Zunyi Medical University
2013-2024
Peking University People's Hospital
2017-2023
National Natural Science Foundation of China
2023
Peking University
2017-2023
A close view of the paraventricular thalamus The is a relay station connecting brainstem and hypothalamic signals that represent internal states with limbic forebrain performs associative functions in emotional contexts. Zhu et al. found thalamic neurons multiple salient features sensory stimuli, including reward, aversiveness, novelty, surprise. nucleus thus provides context-dependent salience encoding. gates information contributes to sleep-wake cycle through its interactions cerebral...
Proper timing of vigilance states serves fundamental brain functions. Although disturbance sleep onset rapid eye movement (SOREM) is frequently reported after orexin deficiency, their causal relationship still remains elusive. Here, we further study a specific subgroup neurons with convergent projection to the REM promoting sublaterodorsal tegmental nucleus (OX SLD neurons). Intriguingly, although OX and other projection-labeled exhibit similar activity dynamics during sleep, only activation...
Retinal ganglion cells (RGCs) receive excitatory glutamatergic input from ON and OFF bipolar in distinct sublaminae of the inner plexiform layer (IPL). AMPA NMDA receptors (AMPARs NMDARs) mediate inputs both synaptic layers, but specific roles for NMDARs at RGC synapses remain unclear. comprise NR1 NR2 subunits are anchored by membrane-associated guanylate kinases (MAGUKs), it is unknown whether particular associate preferentially with splice variants MAGUKs. Here, we used postembedding...
Abstract The relationship between orexin/hypocretin and rapid eye movement (REM) sleep remains elusive. Here, we find that a proportion of orexin neurons project to the sublaterodorsal tegmental nucleus (SLD) exhibit REM sleep-related activation. In SLD, directly excites receptor-positive (occupying ~3/4 total-population) increases gap junction conductance among neurons. Their interaction spreads orexin-elicited partial-excitation activate SLD network globally. Besides, activated exhibits...
Background To identify differentially expressed lipid metabolism-related genes (DE-LMRGs) responsible for immune dysfunction in sepsis. Methods The hub were screened using machine learning algorithms, and the cell infiltration of these assessed by CIBERSORT Single-sample GSEA. Next, function at single-cell level validated comparing multiregional landscapes between septic patients (SP) healthy control (HC). Then, support vector machine-recursive feature elimination (SVM-RFE) algorithm was...
Abstract At most excitatory synapses, AMPA and NMDA receptors (AMPARs NMDARs) occupy the postsynaptic density (PSD) contribute to miniature currents (mEPSCs) elicited by single transmitter quanta. Juxtaposition of AMPARs NMDARs may be crucial for certain types synaptic plasticity, although extrasynaptic also contribute. evoked EPSCs in retinal ganglion cells (RGCs), but mEPSCs are mediated solely AMPARs. Previous work indicates that an NMDAR component emerges when glutamate uptake is...
NMDA receptors (NMDARs) are tetrameric protein complexes usually comprising two NR1 and NR2 subunits. Different combinations of four potential subunits (NR2A-D) confer diversity in developmental expression, subsynaptic localization, functional characteristics, including affinity for neurotransmitter. NR2B-containing NMDARs, example, exhibit relatively high both glutamate the coagonist glycine. Although multiple NMDAR subtypes can colocalize at individual synapses, particular often mediate...
Background: Hemorrhagic shock was a leading cause of death worldwide, with myocardial injury being primary affected organ. As commonly used solutions in fluid resuscitation, acetated Ringer's (AR) and Lactate solution (LR) were far from perfect for their adverse reactions such as lactic acidosis electrolyte imbalances. In previous studies, TPP@PAMAM-MR (TPP-MR), novel nanocrystal resuscitation has been found to protect against septic rats. However, its role rats hemorrhagic underlying...
Despite the attractiveness of ion channels as therapeutic targets, there are no examples monoclonal antibodies directed against in clinical development. Antibody-mediated inhibition could offer a directed, specific approach. To investigate potential inhibiting channel function with an antibody, we focused on Orai1, pore subunit calcium responsible for store-operated entry (SOCE) T cells. Effector cells key drivers autoimmune disease pathogenesis and signaling is essential cell activation,...
Abstract Study Objectives Increased incidence of narcolepsy was reported in children during the 2009 H1N1 pandemic following Pandemrix, a flu vaccine. A link with A(H1N1) pdm09 infections remains controversial. Using nationwide surveillance data from China (1990 to 2017), epidemiology analyzed. Methods Individual records patients were collected 15 42 hospitals across known diagnose cases. Incidence estimated assuming representativeness these hospitals. Age-specific incidence, epidemiological...
Few studies have analyzed the clinicopathologic characteristics and outcomes of lupus nephritis (LN) patients with antineutrophil cytoplasmic antibody (ANCA). The clinical renal histopathologic data 154 biopsy-proven LN from 2011 to 2013 were retrospectively. followed up for a median period 16.8 ± 9.4 months, their analyzed. Multivariate Cox analysis was used evaluate independent factors poor outcomes. Among patients, 26 (16.88%) seropositive ANCA. incidences alopecia, oral ulcer,...
The present study was aimed to evaluate resting-state functional connectivity and topological properties of brain networks in narcolepsy patients compared with healthy controls. Resting-state fMRI performed 26 adult 30 matched MRI data were first analyzed by group independent component analysis, then a graph theoretical method applied the whole brain. Small-world network parameters nodal measured. Altered areas between groups selected as region-of-interest seeds, among these seeds groups....
The latest studies have demonstrated that aberrant expression of microRNA-146a is related to cognitive decline. rs57095329 polymorphism occurring in the miR-146a promoter modulates its and causes downstream pathogenicity. A case-control study a Chinese Han population was established investigate genetic association between postoperative dysfunction (POCD). 242 patients with POCD another 238 non-POCD cases were enrolled study. Serum levels detected by qRT-PCR. genotyped using ABI PRISM...
An asymmetric exo-Diels-Alder reaction of α-methylene carbonyl compounds, generated in situ from stable methiodide salts Mannich bases, with 2,4-dienals, has been developed through trienamine activation a chiral secondary amine. A spectrum spirocyclanes high molecular complexity was efficiently constructed moderate to excellent diastereo- and enantioselectivity.
Accumulated soluble amyloid beta- (A β -) induced aberrant neuronal network activity may directly contribute to cognitive deficits, which are the most outstanding characteristics of Alzheimer’s disease (AD). The entorhinal cortex (EC) is one earliest affected brain regions in AD. Impairments EC neurons responsible for deficits However, little effort has been made investigate effects A on discharge properties vivo . present study was designed examine 1−42 neurons, using extracellular single...
Seizures induce the release of excitatory amino acids (EAAs) from intracellular fluid to extracellular fluid, and released EAAs primarily comprise glutamic acid (Glu) asparaginic (Asp). Glu neurotransmission functions via EAA transporters (EAATs) maintain low concentrations in space avoid excitotoxicity. EAAT2, most abundant transporter subtype central nervous system (CNS), plays a key role regulation glutamate transmission. Previous studies have shown that SB203580 promotes EAAT2 expression...