A5089443665- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- RNA modifications and cancer
- CNS Lymphoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Single-cell and spatial transcriptomics
- DNA Repair Mechanisms
- Viral-associated cancers and disorders
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
Nanjing Medical University
2023
Nanjing General Hospital of Nanjing Military Command
2022-2023
Nanjing University
2022-2023
Jinling Institute of Technology
2022
Abstract Background Undifferentiated carcinoma with osteoclast-like giant cells (OGCs) of pancreas (UCOGCP) is a rare subtype pancreatic ductal adenocarcinoma (PDAC), which had poorly described histopathological and clinical features. Methods In this study, single-cell RNA sequencing (scRNA-seq) was used to profile the distinct tumor microenvironment UCOGCP using samples obtained from one patient three PDAC patients. Bioinformatic analysis carried out immunohistochemical (IHC) staining...
Poly(ADP-ribose) polymerase inhibitors (PARPis) induce DNA lesions that preferentially kill homologous recombination (HR)-deficient breast cancers induced by BRCA mutations, which exhibit a low incidence in cancer, thereby limiting the benefits of PARPis. Additionally, cancer cells, particularly triple-negative (TNBC) HR and PARPi resistance. Therefore, targets must be identified for inducing deficiency sensitizing cells to Here, we reveal CXorf56 protein increased repair TNBC interacting...
Abstract Junctional adhesion molecular 3 (JAM3) is downregulated by hypermethylation in cancers but unclear cholangiocarcinoma. The JAM3 expression level was checked cholangiocarcinoma cell lines and tissues. Methylated detected lines, tissues plasma cell‐free DNAs (cfDNA). roles of were studied transfection siRNA pCMV3‐JAM3. survival analysis based on the Gene Set Cancer Analysis (GSCA) database. HCCC‐9810 HuCCT1 hypermethylation. cfDNAs with 53.3% sensitivity 96.6% specificity....
Objective: To investigate the clinicopathological features and treatment strategies of pituicytoma. Methods: Twenty-one cases pituicytoma were collected at First Affiliated Hospital Nanjing Medical University Jinling Hospital, Nanjing, China from 2009 to 2020. The clinical data 21 patients was retrospectively analyzed, relevant literature reviewed. Results: aged 4 68 years, including 8 males 13 females. All underwent surgical treatment. Histologically, tumor consisted almost entirely...