A5083242432- Influenza Virus Research Studies
- interferon and immune responses
- Enzyme Structure and Function
- Protein Structure and Dynamics
- RNA and protein synthesis mechanisms
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Biochemical and Molecular Research
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- HIV/AIDS drug development and treatment
Institute of Molecular Biology
2024
Abstract The coronavirus disease 19 pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has led to a global health crisis with millions of confirmed cases and related deaths. main protease (Mpro) SARS-CoV-2 is crucial for viral replication presents an attractive target drug development. Despite the approval some drugs, search effective treatments continues. In this study, we systematically evaluated 342 holo-crystal structures Mpro identify optimal conformations...
Influenza virus remains a major public health challenge due to its high morbidity and mortality seasonal surge. Although antiviral drugs against the influenza are widely used as first-line defense, undergoes rapid genetic changes, resulting in emergence of drug-resistant strains. Thus, new that can outwit resistant strains significant importance. Herein, we deep reinforcement learning (RL) algorithm design chemical entities (NCEs) able bind native H275Y mutant (oseltamivir-resistant)...