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Luigui Lima de Castro

ORCID: 0009-0005-1722-8575
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A5068619557
Research Areas
  • Male Reproductive Health Studies
  • Science and Education Research
  • Healthcare during COVID-19 Pandemic
  • Insect and Pesticide Research
  • Trypanosoma species research and implications
  • Research on Leishmaniasis Studies

Universidade do Estado do Amazonas
 2023

 Treatment of cutaneous leishmaniasis with a sequential scheme of pentamidine and tamoxifen in an area with a predominance of Leishmania (Viannia) guyanensis: A randomised, non‐inferiority clinical trial
OPENALEX - Publications 
Silmara Navarro Pennini Jorge Augusto de Oliveira Guerra Paula Frassinetti Bessa Rebello Marília Rosa Abtibol‐Bernardino Luigui Lima de Castro and 10 more Antônio Alcirley da Silva Balieiro Cynthia de Oliveira Ferreira Ariani Batista Noronha C Silva André Luiz Leturiondo Denison Vital de Jesus Felipe Jules de Araújo Santos Anette Chrusciak‐Talhari Maria das Graças Vale Barbosa Guerra Sinésio Talhari

Abstract Objective To determine whether a combination of single intramuscular (IM) dose pentamidine (7 mg/kg) followed by oral tamoxifen 40 mg/day for 20 days is non‐inferior to three IM doses 7 mg/kg in the treatment cutaneous leishmaniasis with margin 15%. Methods Phase II, randomised, controlled, open‐label, non‐inferiority clinical trial. Primary outcome was complete healing lesions 6 months after starting treatment. Secondary outcomes were 3 and determining presence severity adverse...

10.1111/tmi.13943 article EN Tropical Medicine & International Health 2023-11-08
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