A5001643467- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Blood properties and coagulation
- Cancer Treatment and Pharmacology
- Peptidase Inhibition and Analysis
- Elasticity and Material Modeling
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Antibiotics Pharmacokinetics and Efficacy
- Multiple Myeloma Research and Treatments
- Nitric Oxide and Endothelin Effects
- Vitamin K Research Studies
- Blood Pressure and Hypertension Studies
- Cardiac Fibrosis and Remodeling
- Parathyroid Disorders and Treatments
- Thermoregulation and physiological responses
- Autophagy in Disease and Therapy
- Metabolism, Diabetes, and Cancer
- Chronic Myeloid Leukemia Treatments
- Electron Spin Resonance Studies
- Hemodynamic Monitoring and Therapy
- Protease and Inhibitor Mechanisms
- Cerebrovascular and Carotid Artery Diseases
University of Antwerp
2021-2025
Abstract Background The anthracycline doxorubicin (DOX) is a highly effective anticancer agent, especially in breast cancer and lymphoma. However, DOX can cause therapy-related cardiovascular toxicity (CTR-CVT) patients during treatment survivors. Current diagnostic criteria for CTR-CVT focus mainly on left ventricular systolic dysfunction, but certain level of damage required before it be detected. As diastolic dysfunction often precedes the current study aimed to identify functional...
Tyrosine kinase inhibitors (TKIs) targeting vascular endothelial growth factor (VEGF) receptor signalling are used in cancer therapy to inhibit angiogenesis. Unfortunately, VEGF known induce severe hypertension patients. This study aimed elucidate the impact of TKI lenvatinib on blood pressure, arterial stiffness, reactivity, as well cardiac function a short-term murine model shed light potential contributors cardiovascular (CV) toxicities associated with inhibition. Male C57BL/6J mice were...
Abstract Background Fluoroquinolones (FQ) have been associated with aortic aneurysm and dissection (AA/AD) resulting in an official warning. Recently, large-scale epidemiological studies failed to confirm this. Objectives The current study aimed scrutinise the FQ-AA/AD association through a retrospective nested case-cohort analysis supplemented animal experimentation. Results FQ exposure was not increased AA/AD hazard ratios main high-risk (elderly ≥65 years, hypertensive, prevalent disease)...
Clinical and animal studies have demonstrated that chemotherapeutic doxorubicin (DOX) increases arterial stiffness, a predictor of cardiovascular risk. Despite consensus about DOX-impaired endothelium-dependent vasodilation as contributing mechanism, some reported conflicting results on vascular smooth muscle cell (VSMC) function after DOX treatment. The present study aimed to investigate the effects VSMC function. To this end, mice received single injection 4 mg DOX/kg, or mouse aortic...
Arterial stiffness is a hallmark of vascular ageing and results in increased blood flow pulsatility to the periphery, damaging end-organs such as heart, kidneys brain. Treating or "reversing" arterial has therefore become central target field ageing. SGLT2 inhibitors, initially developed context type 2 diabetes mellitus, have cornerstone heart failure treatment. Additionally, effects on vasculature been reported. Here, we demonstrate that treatment with inhibitor empagliflozin (7 weeks, 15...
Proteasome inhibitors such as bortezomib and carfilzomib induce apoptosis are a cornerstone in the treatment of relapsed or refractory multiple myeloma. However, concerns have emerged concerning their link to cancer therapy-related cardiovascular dysfunction (CTRCD). Bortezomib, reversible first-generation inhibitor, carfilzomib, second-generation irreversible associated with hypertension, heart failure, cardiac arrhythmias. The current study investigated effects on (left ventricular...
Due to its viscoelastic properties, the aorta aids in dampening blood pressure pulsatility. At level of resistance-arteries, pulsatile flow will be transformed into a continuous allow for optimal perfusion end organs such as kidneys and brain. In this study, we investigated ex vivo properties different regions healthy C57Bl6/J adult mice well interplay between (altered) cyclic stretch viscoelasticity. We demonstrated that parameters increase along distal effect altered is region dependent....
Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta influence aging. Aortic segments 12 week 24 month old (both n = 6) male C57BL/6J mice were mounted in Rodent Oscillatory Set-up Compliance, order measure reactivity. Regional variations evident, with abdominal infrarenal (AIA) exhibiting highest smallest...
Arterial stiffening is a hallmark of vascular ageing, and unravelling its underlying mechanisms has become central theme in the field cardiovascular disease. While various techniques experimental setups are accessible for investigating biomechanics blood vessels both vivo ex vivo, comparing findings across diverse methodologies challenging. In present study, we aimed to compare arterial stiffness measurements two distinct measuring aortic mechanics. First, measured aorta adult (5 months)...
Background and Aims: Fluoroquinolones (FQ) have been linked to aortic aneurysms dissections (AA/AD), resulting in an official warning. However, recent large-scale epidemiological studies reported lack of FQ-AA/AD association. This study aimed scrutinize risk by implementing a combined experimental approach. Methods: Danish nationwide registers (2003-2021) were used for nested case-control analysis. was evaluated main high-risk FDA cohort. Further, mortality interventions FQ investigated...
Abstract Introduction Neuregulin-1 (NRG-1) is a growth factor derived from endothelial cells and belongs to the epidermal (EGF) family. While NRG-1 expressed by various cell types, including epithelial cells, glial neurons, myocytes, primary source of considered be endothelium. exerts its effects through EGF receptors ERBB2, ERBB3, ERBB4. Upon ligand binding, these dimerize become phosphorylated, leading downstream signaling that impacts tissue proliferation, differentiation, survival. The...
Introduction: Arterial stiffening is a hallmark of vascular ageing, and unravelling its underlying mechanisms has become central theme in the field cardiovascular disease. While various techniques experimental setups are accessible for investigating biomechanics blood vessels both vivo ex vivo, comparing findings across diverse methodologies challenging. Methods: stiffness aorta adult (5 months) aged (24 wild-type C57Bl/6J mice was measured after which biomechanical evaluation performed...
Arterial stiffness is a hallmark of vascular ageing and results in increased blood flow pulsatility to the periphery, damaging end-organs such as heart, kidneys brain. Treating or “reversing” arterial has therefore become central target field ageing. SGLT2 inhibitors, initially developed context type 2 diabetes mellitus, have cornerstone heart failure treatment. Additionally, effects on vasculature been reported. Here, we demonstrated that treatment with inhibitor empagliflozin (7 weeks, 15...