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Hao-Hsuan Tsai

ORCID: 0009-0005-2276-9886
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About
Contact & Profiles
A5103216027
Research Areas
  • Parathyroid Disorders and Treatments
  • Kruppel-like factors research
  • Phagocytosis and Immune Regulation
  • Genetic Syndromes and Imprinting
  • Fibroblast Growth Factor Research
  • Heterotopic Ossification and Related Conditions
  • Biomedical Research and Pathophysiology
  • Bariatric Surgery and Outcomes

Northwestern University
 2022-2023

 FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice
OPENALEX - Publications 
Guillaume Courbon Dominik Kentrup Jane Joy Thomas Xueyan Wang Hao-Hsuan Tsai and 11 more Jadeah J. Spindler John Von Drasek Laura C.M. Ndjonko Marta Martínez‐Calle Emily P. Lynch Lauriane Hivert Xiaofang Wang Wenhan Chang Jian Q. Feng Valentin David Aline Martin

Fibroblast growth factor 23 (FGF23) is a phosphate (Pi)-regulating hormone produced by bone. Hereditary hypophosphatemic disorders are associated with FGF23 excess, impaired skeletal and osteomalacia. Blocking became an effective therapeutic strategy in X-linked hypophosphatemia, but testing remains limited autosomal recessive rickets (ARHR). This study investigates the effects of Pi repletion bone specific deletion Fgf23 on mineral metabolism Dmp1 knockout (Dmp1KO) mouse model ARHR.At 12...

10.1172/jci.insight.156850 article EN cc-by JCI Insight 2023-11-09
 Fibroblast Growth Factor 23 Directly Contributes to CKD Progression in Col4a3 Knockout Mice
OPENALEX - Publications 
Dominik Kentrup Hao-Hsuan Tsai Xueyan Wang Jane Joy Thomas Jadeah J. Spindler and 2 more Valentin David Aline Martin

10.1681/asn.202454d3pm80 article EN Journal of the American Society of Nephrology 2024-10-01
 Direct Effects of FGF23 on Osteoblasts Contribute to Bone Defects in Dmp1KO Mice Independently of Phosphate
OPENALEX - Publications 
Dominik Kentrup Guillaume Courbon Hao-Hsuan Tsai Xueyan Wang John C. Von Drasek and 4 more Jadeah J. Spindler Lauriane Hivert Valentin David Aline Martin

Kentrup, Dominik; Courbon, Guillaume; Tsai, Hao-Hsuan; Wang, Xueyan; Drasek, John C. Von; Spindler, Jadeah J.; Hivert, Lauriane; David, Valentin; Martin, Aline Author Information

10.1681/asn.20233411s110c article EN Journal of the American Society of Nephrology 2023-11-01
 Severe Bone Loss Occurs in Slow but Not in Fast CKD Progression
OPENALEX - Publications 
Hao-Hsuan Tsai Dominik Kentrup Xueyan Wang Bridget Hunt-Tobey Jadeah J. Spindler and 3 more John C. Von Drasek Valentin David Aline Martin

Tsai, Hao-Hsuan; Kentrup, Dominik; Wang, Xueyan; Hunt-Tobey, Bridget; Spindler, Jadeah J.; Von Drasek, John C.; David, Valentin; Martin, Aline Author Information

10.1681/asn.20223311s1661c article EN Journal of the American Society of Nephrology 2022-11-01
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