A5012565486- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Birth, Development, and Health
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
University of California, San Francisco
2023-2025
Mayo Clinic
2024
WinnMed
2024
Intratumoral heterogeneity (ITH)-defined as genetic and cellular diversity within a tumor-is linked to failure of immunotherapy an inferior anti-tumor immune response. We modeled heterogeneous tumors comprised "hot" "cold" tumor populations (giving rise T cell-rich cell-poor tumors, respectively) introduced fluorescent labels enable precise spatial tracking. found the cold cell population exerted "dominant cold" effect in mixed tumors. Strikingly, analysis revealed that cells themselves...
Abstract Intratumoral heterogeneity (ITH)—defined as genetic and cellular diversity within a tumor—is linked to failure of immunotherapy an inferior anti-tumor immune response. The underlying mechanism this association is unknown. To address question, we modeled heterogeneous tumors comprised pro-inflammatory (“hot”) immunosuppressive (“cold”) tumor population, labeled with YFP RFP tags respectively enable precise spatial tracking. resulting mixed-population exhibited distinct regions +...
Introduction Postpartum preeclampsia (PPPE) is an under-diagnosed condition, developing within 48 hours to 6 weeks following uncomplicated pregnancy. The etiology of PPPE still unknown, leaving patients vulnerable and making the identification treatment requiring postpartum care unmet need. We aimed understand immune contribution at time diagnosis, as well uncover predictive potential perinatal biomarkers for early postnatal high-risk patients. Methods Placentas were collected delivery from...
Abstract Intratumoral heterogeneity (ITH) – cellular and molecular diversity within a tumor is linked to failure of immunotherapy in multiple cancer types. A high degree ITH associated with poor infiltration T cells into the resistance immune checkpoint blockade (ICB) therapy. To determine how distinct populations heterogeneous tumors shape microenvironment this impacts therapy response, we modeled composed an RFP-tagged immunosuppressive population YFP-tagged pro-inflammatory population....
<h3>Background</h3> Intratumoral heterogeneity—defined as genetic and cellular diversity within a tumor—is linked to the failure of immunotherapy in multiple cancer types.<sup>1 2</sup> The reasons for this are not well understood. Recent multi-region studies have found that many two-thirds patient tumors contain both distinct 'hot' 'cold' tumor regions, defined by high low T cell infiltrates, respectively.<sup>3</sup> We developed novel system reproducibly model heterogeneity mice, employed...