A5103191624- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Head and Neck Cancer Studies
- Single-cell and spatial transcriptomics
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
Arrakis Therapeutics (United States)
2024
Southern Illinois University School of Medicine
2016-2017
Platinum-based therapy is most often used to treat advanced cases of head and neck cancers, but only a small fraction the patient population responds cisplatin, with median survival time less than year. Although gene signatures molecular etiology cancers have been previously described, none them are predictive indicators cisplatin treatment response in particular. Therefore, currently, there lack clinically employable disease beyond HPV status specifically predict patients' platinum-based...
The loss of RAB25 expression-RAS superfamily GTPase characteristic numerous breast cancers-corresponds with H-RAS point mutations, particularly in triple-negative cancers (TNBC), a subtype associated poor prognosis. To address the poorly understood factors dictating progression TNBC tumors, we examine cooperative effects that expression human mammary epithelial cell (HMEC) lines mutations confers tumorigenesis. HMECs were immortalized by transduction LXSN CDK4 R24C, mutant form...
Primary human mammary epithelial cells have a limited life span which makes it difficult to study them in vitro for most purposes. To overcome this problem, we developed cell line that was immortalized using defined genetic elements, and characterized non-tumorigenic establish as potential model system. were obtained from healthy individual undergoing reduction mammoplasty at SIU School of Medicine. The transduced with CDK4R24C followed by transduction telomerase reverse transcriptase. Post...
Abstract The RAB guanosine triphosphates (RAS-related in brain) belong to the Ras superfamily of GTPases, and loss 25 expression has been reported a number breast cancer cases containing H-Ras point mutations, particularly triple negative cancers (TNBC), one most aggressive subtypes associated with poor prognosis. mechanism involved progression these tumors is poorly understood. In this study, we are trying understand if RAB25 Human Mammary Epithelial Cell (HMEC) lines co-operates mutations...