A5090175287- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes Management and Research
- Parasitic Infections and Diagnostics
- Acute Lymphoblastic Leukemia research
- Polyomavirus and related diseases
- Carcinogens and Genotoxicity Assessment
- Radiation Effects and Dosimetry
- Cancer Immunotherapy and Biomarkers
- Pneumocystis jirovecii pneumonia detection and treatment
- Effects of Radiation Exposure
- Antifungal resistance and susceptibility
Leiden University Medical Center
2011-2022
Leiden University
1993-2000
In this phase 4, multicentre, prospective, non-interventional PIONEER REAL Netherlands study, we assessed clinical outcomes associated with once-daily oral semaglutide use in real-world practice adults living type 2 diabetes (T2D) naïve to injectable glucose-lowering medication. Participants initiated on were followed for 34–44 weeks. Change glycated haemoglobin (HbA1c) from baseline (BL) end of study (EOS) was the primary endpoint; secondary endpoints included change body weight (BW) BL...
The effect of recombinant rat interferon-gamma (rIFN-gamma) on acute disseminated Candida albicans infection in mice was investigated. Outgrowth C. kidneys, spleen, and liver treated with one intravenous (iv) dose rIFN-gamma before iv injection 5 x 10(5) cfu significantly lower than controls over 7 days. protective when given 1 day before, simultaneously with, or 1-3 days after but not 3 before. In pretreated hydrocortisone acetate, reduced the outgrowth only 10(3) injected. Injection did...
Abstract Adoptive cellular therapies with T cells are increasingly used to treat a variety of conditions. For instance, in recent phase 1/2 trial, we prophylactically administered multivirus-specific T-cell products protect recipients T-cell–depleted allogeneic stem cell grafts against viral reactivation. To establish treatment efficacy, it is important determine the fate individual transferred populations. However, difficult unequivocally distinguish progeny from recipient- or graft–derived...
Although the in-vitro induction of leukemia-reactive T cells from naïve donor repertoire has been shown to be feasible, robustness procedure is limited. In this study, we investigated role frequencies antigen-specific precursor (Tprec) and regulatory (Treg), number antigen presenting (APC), targeted antigens (Ag) on ability prime, enrich expand Ag-specific primary immune responses in-vitro. Therefore, developed an model system allowing quantitative functional monitoring activation...