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Subhecchha Baidya

ORCID: 0009-0005-4852-246X
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A5066304749
Research Areas
  • Tuberculosis Research and Epidemiology
  • Antibiotic Resistance in Bacteria
  • Cancer therapeutics and mechanisms

Indian Institute of Technology Roorkee
 2021

 Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs
OPENALEX - Publications 
Sourya Bhattacharya Vivek Junghare Niteesh Kumar Pandey Subhecchha Baidya Harsha Agarwal and 6 more Neeladrisingha Das Ayan Banerjee Debashish Ghosh Partha Roy Hirak K. Patra Saugata Hazra

The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for an immediate search novel treatment strategies. Recently, BlaC, the principal beta-lactamase Mycobacterium tuberculosis, was recognized as a potential therapeutic target. BlaC belongs to Ambler class A, which is generally susceptible inhibitors currently used in clinics: tazobactam, sulbactam, clavulanate. Alterations at Ser130 conserved SDN loop confer resistance mechanism-based (MBIs)...

10.3389/fmicb.2021.710291 article EN cc-by Frontiers in Microbiology 2021-10-08
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