A5018281598- Reconstructive Surgery and Microvascular Techniques
- Breast Implant and Reconstruction
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Protein Kinase Regulation and GTPase Signaling
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- Medical Imaging Techniques and Applications
- Body Contouring and Surgery
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Reconstructive Facial Surgery Techniques
- Cancer Diagnosis and Treatment
- Genetic factors in colorectal cancer
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lysosomal Storage Disorders Research
- Pain Mechanisms and Treatments
- Subterranean biodiversity and taxonomy
Cleveland Clinic
2022-2025
Cleveland Clinic Lerner College of Medicine
2021-2024
Case Western Reserve University
2021-2024
Saint Louis University
2023
Creative Commons
2022-2023
The Ohio State University
2020-2022
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2021
Charité - Universitätsmedizin Berlin
2016-2020
Kenyon College
2016-2017
University of Arizona
2012-2015
Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors driven by populations of cancer stem cells (CSCs). However, few molecular mechanisms critical for CSC population maintenance have been exploited therapeutic development. We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators the SOX2-enriched, therapy-resistant niche and identified WDR5 as indispensable this population. is component WRAD complex,...
Deep inferior epigastric perforator (DIEP) flaps are the standard for autologous breast reconstruction. This study investigated risk factors DIEP complications in a large, contemporary cohort to optimize surgical evaluation and planning.This retrospective included patients who underwent reconstruction between 2016 2020 at an academic institution. Demographics, treatment, outcomes were evaluated univariable multivariable regression models postoperative complications.In total, 802 performed...
Chemotherapy-induced peripheral neuropathy accompanied by neuropathic pain (CIPN) is a major neurotoxicity of cisplatin, platinum-based drug widely used for lung, ovarian, and testicular cancer treatment. CIPN causes discontinuation severely impacts life quality with no FDA-approved interventions. We previously reported that drugs increase levels sphingosine 1-phosphate (S1P) in the spinal cord drive through activating S1P receptor subtype 1 (S1PR1). However, mechanisms engaged downstream...
Window chamber models have been developed and utilized as a means to study the complex microenvironment in which cancers develop, proliferate, metastasize small animals. Here we utilize rapid prototyping printer technology construct new plastic orthotopic mammary window that is compatible with magnetic resonance imaging, nuclear optical imaging. Optical imaging allows for high-resolution cellular molecular level analysis of tissues; provides quantitative measures tumor size, perfusion,...
Background This study aimed to identify patient preferences and outcomes of chest masculinization surgery in patients identifying as nonbinary versus transgender (trans-) males. Methods Patients who underwent (2003–2022) were included. Demographics, medical comorbidities, surgical approaches, complications, secondary procedures, BODY-Q module survey responses compared between cohorts. Results Three hundred two Thirteen percent identified 87% trans-male. The most common approach both groups...
Abstract Background Breast cancer (BC) is the most common in women and leading cause of cancer-associated mortality women. In particular, triple-negative BC (TNBC) has highest rate due large part to lack targeted treatment options for this subtype. Thus, there an urgent need identify new molecular targets TNBC treatment. RALA RALB are small GTPases implicated growth metastasis a variety cancers, although little known their roles BC. Methods The necessity tumor were evaluated vivo using...
Deep inferior epigastric perforator (DIEP) flaps are commonly used for autologous breast reconstruction, but reported rates of venous thromboembolism (VTE) up to 6.8%. This study aimed determine the incidence VTE based on preoperative Caprini score following DIEP reconstruction. retrospective included patients who underwent reconstruction between January 1, 2016 and December 31, 2020 at a tertiary-level, academic institution. Demographics, operative characteristics, events were recorded....
Amphibian metamorphosis is driven by thyroid hormone (TH). We used prometamorphic tadpoles and a cell line of the African clawed frog (Xenopus laevis) to examine immediate effects dioxin exposure on TH. Gene expression patterns suggest cross-talk between receptor (TR) aryl hydrocarbon (AHR) signaling pathways. In XLK-WG cells, Cytochrome P450 1A6 (cyp1A6), an AHR target, was induced 1000-fold 100 nM TCDD (2, 3, 7, 8 tetrachlorodibenzo-p-dioxin). Krüppel-Like Factor 9 (klf9), first gene in...
Background: Breast reconstruction following mastectomy for the treatment of breast cancer restores form and enhances patient satisfaction. The Affordable Care Act (ACA) 2010 aimed to impact trends in reconstruction, but recent information regarding racial ethnic disparities is lacking. Methods: We analyzed National Surgical Quality Improvement Program (NSQIP) data spanning 2005-2022 investigate ACA on diversity immediate post-mastectomy. Patient demographics, including race ethnicity, were...
Phosphorescent lifetime imaging was employed to measure the spatial and temporal distribution of oxygen partial pressure in tissue under coverslip a mammary window chamber breast cancer mouse model. A thin platinum-porphyrin coating, whose phosphorescent varies monotonically with pressure, applied surface. Dynamic responses induced modulations oxygenation levels were measured using this approach.
Combining multiple surgical procedures into a single operative session is widespread in the field of plastic surgery; however, implications this practice are not fully understood.This study compared 30-day complication rates associated with combined surgery for index procedures.This retrospective cohort analysis utilized Tracking Operations and Outcomes Plastic Surgeons database from 2016 to 2020 identify 3 most frequent combinations augmentation mammaplasty, reduction trunk liposuction,...
The development and implementation of a scientific outreach activity comes with number challenges. A successful event must match the sophistication content to audience, be engaging, expand knowledge base for participants, inclusive diverse audience. Ideally, will also convey importance future scientists citizens. In this paper, we present simple, hands-on guide targeted kindergarten learners. This pursued second goal: inclusion undergraduate students in delivery event. We provided detailed...
Upregulate levels of expression and activity membrane H<sup>+</sup> ion pumps in cancer cells drives the extracellular pH (pH<sub>e</sub>,) to values lower than normal. Furthermore, disregulated is indicative changes glycolytic metabolism tumor has been shown facilitate tissue remodeling during metastasis Therefore, measurement pH<sub>e</sub> could be a useful biomarker for diagnostic therapy monitoring evaluation. Multimodality in-vivo imaging tumorous mouse dorsal skin fold window chamber...
Introduction: The cold shock Y-box binding protein-1 (YB-1) fulfills important roles in regulating cell proliferation and differentiation. Overexpression occurs various tumor cells. Given the existence of extracellular YB-1 we set out to determine diagnostic, predictive prognostic role serum YB-1/p18 for patients with primary epithelial ovarian cancer (EOC).
Breast anesthesia and hypoesthesia occur commonly after mastectomy negatively impact quality of life. Neurotization during deep inferior epigastric perforator (DIEP) breast reconstruction offers enhanced sensory recovery. However, access to neurotization for DIEP patients has not been evaluated.
Mastectomy is performed prior to or concurrently with deep inferior epigastric perforator (DIEP) flap breast reconstruction. However, the complication rates of nipple-sparing mastectomy (NSM) versus skin-sparing (SSM) DIEP are not well-characterized.
Window chamber models have been utilized for many years to investigate cancer development and the tumor microenvironment. Orthotopic mammary window model developed detailed study of breast cancer. models, due native environment, support more realistic growth behavior than ectopic models. The work by other groups thus far utilizing has focused solely on optical imaging techniques, limited probing first millimeter or less tissue. These techniques do not take full advantage unrestricted,...
Recent evidence suggests that epithelial ovarian cancer may originate in the fimbriated end of fallopian tube<sup>1</sup>. Unlike many other cancers, poor access to ovary and tubes has limited ability study progression this deadly disease diagnosis it during early stage when is most amenable therapy. We have previously reported on a rigid confocal microlaparoscope system currently undergoing clinical trial image surface ovary<sup>2</sup>. In order gain vivo we developed new with an...
Purpose: Combining several surgical procedures into one operative session is widespread in the field of plastic surgery; however, implications this practice are not fully understood. This study aimed to evaluate rates and characteristics adverse events associated with combining surgery as compared outcomes individual alone. Methods: A retrospective cohort analysis was performed utilizing data between 2016 2020 from TOPS database. The three most frequent combinations for each five commonly...
Abstract Glioblastomas (GBMs) are heterogeneous, treatment-resistant tumors that driven by populations of cancer stem cells (CSCs). Despite their importance for tumor growth, few molecular mechanisms critical CSC population maintenance have been exploited therapeutic development. We developed a spatially resolved loss-of-function screen in GBM patient-derived organoids to identify essential epigenetic regulators the SOX2-enriched, therapy resistant niche and identified WDR5 as indispensable...