A5093908030- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Gut microbiota and health
- Bacterial Identification and Susceptibility Testing
- Clostridium difficile and Clostridium perfringens research
- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
NIHR Birmingham Biomedical Research Centre
2024
National Institute for Health Research
2024
University Hospitals Birmingham NHS Foundation Trust
2024
University of Birmingham
2024
<ns4:p>Background Hospital-acquired pneumonia (HAP) is an important complication of hospital admission, with both high incidence and consequences for patients. However, our understanding causative organisms prognostic factors limited. Although ventilator-associated (VAP,) subset HAP,has been - extensively investigated, less known about non-ventilated cases, leading to calls focused research in this group. This retrospective observational cohort study aims define a population patients treated...
Non-ventilated hospital acquired pneumonia (NV-HAP) is defined as that develops at least 48 hours after admission in the non-invasively ventilated patient. Guidance management of NV-HAP has historically used extrapolated research from wider field HAP, which includes patients with separate clinical entity ventilator associated (VAP), or community (CAP). However, being increasingly recognised a subtype HAP owing to its high incidence, mortality, morbidity and health-economic burden. With wide...
Introduction Infection causes a vast burden of disease, with significant mortality, morbidity and costs to health-care systems. However, identifying the pathogen causative infection can be challenging, resulting in high use broad-spectrum antibiotics, much which may inappropriate. Novel metagenomic methods have potential rapidly identify pathogens, however their clinical utility for many infections is currently unclear. Outcome from also impacted by effectiveness immune responses, impaired...