A5101722675- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Immune Response and Inflammation
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Multiple Sclerosis Research Studies
- Plant Gene Expression Analysis
- Lipid metabolism and biosynthesis
- Anesthesia and Neurotoxicity Research
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Food Quality and Safety Studies
- interferon and immune responses
- Chromosomal and Genetic Variations
- Botanical Studies and Applications
- RNA and protein synthesis mechanisms
- Immune cells in cancer
- Melanoma and MAPK Pathways
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Cytokine Signaling Pathways and Interactions
- Medicinal Plant Pharmacodynamics Research
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Immunotherapy and Immune Responses
University of Cambridge
2022-2024
National Institute for Health Research
2022
Constructor University
2022
University of Madras
1983
Abstract Sustained smouldering, or low-grade activation, of myeloid cells is a common hallmark several chronic neurological diseases, including multiple sclerosis 1 . Distinct metabolic and mitochondrial features guide the activation diverse functional states 2 However, how these act to perpetuate inflammation central nervous system unclear. Here, using multiomics approach, we identify molecular signature that sustains microglia through complex I activity driving reverse electron transport...
A system of chromosome classification and nomenclature based on arm ratios centromeric indices from both the long short arms is proposed. This will enable one to determine correct position centromere name chromosomes according known locations. table embodying nomenclature, notation, ratio values presented serve as a key for classification. The advantage present over other systems discussed with help few examples.
SUMMARY Progressive multiple sclerosis (PMS) is characterized by a primary smouldering pathological disease process associated with superimposed inflammatory activity. Cellular and molecular processes sustaining the pathobiology of PMS remain to be identified. We previously discovered senescence signatures in neural stem/progenitor cells (NSCs) from people PMS. Applying direct reprogramming generate directly induced NSCs (iNSCs) somatic fibroblasts, we retain epigenetic information observe...
Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role disease pathobiology and contribution to the lesion environment remains unclear. By establishing directly induced stem/progenitor cell (iNSC) lines from PMS patient fibroblasts, we studied senescent phenotype vitro. Senescence was strongly associated inflammatory signaling, hypermetabolism, senescence-associated secretory (SASP). PMS-derived iNSCs...
SUMMARY Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role disease pathobiology and contribution to the lesion environment remains unclear. By establishing directly induced stem/progenitor cell (iNSC) lines from PMS patient fibroblasts, we studied senescent phenotype vitro . Senescence was strongly associated inflammatory signaling, hypermetabolism, senescence secretory (SASP). PMS-derived iNSCs...
Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL Increased Cholesterol Synthesis Drivesneurotoxicity Patient Stem Cell-Derived Model of Multiple Sclerosis 55 Pages Posted: 23 Feb 2024 See all articles by Rosana-Bristena IonescuRosana-Bristena IonescuUniversity CambridgeAlexandra NicaiseUniversity CambridgeJulie A. ReiszUniversity Colorado, Aurora - Department Biochemistry and Molecular...
Abstract The cell biology and biochemistry of peptide exchange on major histocompatibility complex class I (MHC‐I) proteins are great interest in the study immunodominance, which requires iterative optimization affinity, cross‐presentation pathogen tumor antigens, endogenous peptides exchanged for exogenous ones. Even though several methods exist to catalyze recombinant MHC‐I proteins, cellular conditions mechanisms allowing vivo remain unclear. Here, we demonstrate that low pH, as present...
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