A5038343734- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Botulinum Toxin and Related Neurological Disorders
- Salivary Gland Disorders and Functions
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Pharmacological Receptor Mechanisms and Effects
- Diverticular Disease and Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Neuropathies and Disorders
- Diabetes Management and Research
- Nuclear Receptors and Signaling
Seikei University
2025
Froedtert Menomonee Falls Hospital
2024
National Center of Neurology and Psychiatry
2023
The University of Tokyo
2012-2020
Nishijin Hospital
2015-2019
Nagoya University
2015-2019
Toho University
2012-2017
Tachikawa Medical Center
2017
Aichi Gakuin University
2017
St. Mary’s Hospital
2016
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily characterized by the degeneration of dopaminergic neurons in nigrostriatal pathway. Previous studies have demonstrated chronic systemic exposure Lewis rats to rotenone produced many features PD, and cerebral tauopathy was also detected case severe weight loss. The present study designed assess neurotoxicity after daily oral administration for 28 days at several doses C57BL/6 mice. In addition, we examined...
In the present study, we investigated role of macrophage inflammatory protein-1α (MIP-1α) in pathogenesis neuropathic pain following partial sciatic nerve ligation (PSL) mice. MIP-1α mRNA and its protein were dramatically up-regulated after PSL, was localized on macrophages Schwann cells injured (SCN). PSL-induced long-lasting tactile allodynia thermal hyperalgesia prevented by perineural injection anti-MIP-1α (2 ng). Intraneural (20 ng) (100 recombinant elicited sham-operated limb....
There is increasing evidence that inflammatory (M1-polarized) macrophages drive the nonresolving neuroinflammation causes neuropathic pain after nerve injury. As interleukin-4 (IL-4) promotes suppressive (M2-polarized) state in macrophages, we examined whether exploiting an IL-4-mediated pathway could ameliorate M1 macrophage-dependent pain. The mRNA and protein expression of IL-4 receptor α chain (IL-4Rα) were upregulated accumulating F4/80 injured sciatic (SCN). In mouse macrophage cell...
Nerve injury may result in neuropathic pain, characterized by allodynia and hyperalgesia. Accumulating evidence suggests the existence of a molecular substrate for pain produced neurons, glia, immune cells. Here, we show that leptin, an adipokine exclusively adipocytes, is critical development tactile through macrophage activation mice with partial sciatic nerve ligation (PSL). PSL increased leptin expression adipocytes distributed at epineurium injured (SCN). Leptin-deficient animals, ob/ob...
Although there is growing evidence showing that the involvement of chemokines in pathogenesis neuropathic pain associated with neuroinflammation, details are unclear. We investigated C-X-C chemokine ligand type 2 [macrophage inflammatory protein (MIP-2)]/C-X-C receptor (CXCR2) axis and epigenetic regulation these molecules after peripheral nerve injury. Expression MIP-2 CXCR2 were up-regulated localized on accumulated neutrophils macrophages injured sciatic (SCN) partial ligation (PSL)....
Peripheral neuroinflammation caused by activated immune cells can provoke neuropathic pain. Herein, we investigate the actions of macrophages and T through glucocorticoid-induced tumor neurosis factor receptor ligand (GITRL) its (GITR) in After partial sciatic nerve ligation (PSL) enhanced green fluorescent protein (eGFP) chimeric mice generated transplantation eGFP(+) bone marrow cells, macrophages, markedly migrated to injured site after PSL. Administration agents deplete...
Abstract Background Neuropathic pain is caused by neural damage or dysfunction and neuropathic pain‐related symptoms are resistant to conventional analgesics. Neuroinflammation due the cytokine‐chemokine network may play a pivotal role in pain. We demonstrate that macrophage inflammatory protein‐1β ( MIP ‐1β) participates Methods Mice received partial sciatic nerve ligation PSL ), tactile allodynia thermal hyperalgesia were assessed von F rey test H argreaves test, respectively. Agents...
Chronic neuroinflammation may be a critical component of intractable inflammatory diseases, including neuropathic pain. Because angiogenesis as result vascular endothelial growth factor (VEGF) signaling plays pivotal role in inflammation, we focused on the mechanisms VEGF-regulated pain mice. The mRNA and protein expression VEGFA were up-regulated injured sciatic nerve after partial ligation (PSL). was localized to accumulated macrophages neutrophils derived from bone marrow. Up-regulation...
Capsule endoscopy (CE) has high positive (95%) and negative predictive values (83- 100%) for the bleeding source in patients with obscure gastrointestinal (OGIB) but diagnostic yield is influenced by timing of examination nature bleeding.We investigated role early CE diagnosis overt OGIB. Patients were divided into 4 groups according to interval between CE. The rate clinical outcomes including type intervention recurrent compared. association small bowel lesions detected was also...
The present multicenter, prospective, controlled, open and randomized three-arm parallel study was designed to compare the effects of linagliptin with those metformin on endothelial function.Type 2 diabetes patients treated 750 mg (hemoglobin A1c ≥6.0% <8.0%, n = 96) were continue mg/day (control group, 29), at 1,500 (metformin 26) supplemented 5 (linagliptin add-on 29) for 16 weeks. Vascular function evaluated by flow-mediated dilation. primary end-point changes in dilation weeks relative...
Abstract Calreticulin (CRT), a chaperone that possesses both lectin and domains, is localized in the endoplasmic reticulum (ER). CRT has diverse functions localizations; thus, multifunctional protein. Particularly ER, mainly aids proper folding of nascent glycoproteins as chaperones. Approximately one-third cellular proteins, including disease-related are synthesized ER. The chaperones calnexin facilitate correct these glycoproteins; hence, essential for cells. Various ligands have been...