A5026909819- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Electrochemical Analysis and Applications
- Molecular Junctions and Nanostructures
- Food Allergy and Anaphylaxis Research
- Gas Sensing Nanomaterials and Sensors
National Sun Yat-sen University
2024
University of Dundee
2011
Institute of Medical Biology
2011
Null mutations in the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) and predispose to atopic dermatitis (AD). Cohort studies Europe Japan have reported an FLG mutation carrier frequency of between 14% 56%, but prevalent European are rare or absent Chinese patients with IV AD.To investigate further spectrum FLG-null compare it that other populations.We conducted comprehensive genetic analysis a discovery cohort 92 Singaporean individuals and/or moderate-to-severe AD. All detected were...
Atopic dermatitis (AD) is a chronic inflammatory skin condition primarily driven by T helper 2 (Th2) cytokines, resulting in barrier defects, angiogenesis, and responses. The marine natural product excavatolide B (EXCB), isolated from the Formosan Gorgonian coral Briareum stechei, exhibits anti-inflammatory analgesic properties. To enhance solubility, EXCB chemically modified into derivatives EXCB-61 salt EXCB-79. study aims to investigate therapeutic effects of these compounds on...