A5109726135- Orthopaedic implants and arthroplasty
- Water Quality Monitoring Technologies
- Nanoplatforms for cancer theranostics
- Aortic Disease and Treatment Approaches
- Bone health and treatments
- Periodontal Regeneration and Treatments
- Medical Imaging and Pathology Studies
- Water resources management and optimization
- Mechanisms of cancer metastasis
- Wound Healing and Treatments
- Signaling Pathways in Disease
- Lung Cancer Research Studies
- Heterotopic Ossification and Related Conditions
- Clinical Nutrition and Gastroenterology
- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Antimicrobial agents and applications
- Advanced biosensing and bioanalysis techniques
- Healthcare Systems and Challenges
- Mesenchymal stem cell research
- Neuroendocrine Tumor Research Advances
Henan University
2024-2025
Sichuan University
2024-2025
Ministry of Education of the People's Republic of China
2024
West China Hospital of Sichuan University
2024
People's Liberation Army 401 Hospital
2023
Chinese People's Liberation Army
2023
Endochondral ossification generates most of the load-bearing bones, recapitulating it in human cells remains a challenge. Here, we report generation SOX9+ sclerotomal progenitors (scl-progenitors), mesenchymal precursor at pre-condensation stage, from pluripotent stem and development osteochondral induction methods for these cells. Upon lineage-specific induction, scl-progenitors have not only generated articular cartilage but also undergone spontaneous condensation, cartilaginous anlagen...
An injectable hydrogel loading α-N-heterocyclic thiosemicarbazones with antibacterial activity was designed to attain therapy against wounds high efficiency. In the present study, FPZ-H2L synthesized by 2,6-diacetylpyridine bis(N4-methylthiosemicarbazone) (H2L) on transition-metal ions (Zn2+)-cross-linked-folic acid (FA)-co-polydopamine (PDA) (FPZ hydrogel). The (FPZ-H2L) cross-linked coordination and hydrogen bonds displayed an excellent self-healing performance completely covered irregular...
Degenerative bone disorders have a significant impact on global health, and regeneration of articular cartilage remains challenge. Existing cell therapies using mesenchymal stromal cells (MSCs) shown limited efficacy, highlighting the necessity for alternative stem sources. Here, we identified characterized MSX1+ progenitor in developing limb bud with remarkable osteochondral-regenerative microenvironment-adaptive capabilities. Single-cell sequencing further revealed presence two major...
<title>Abstract</title> Drug-tolerant persister cells withstand treatments by adapting their identity through lineage-dependent plasticity during systemic anti-cancer therapies. This phenomenon is evident in small-cell lung carcinoma (SCLC), a lethal neuroendocrine cancer initially responsive (60-80%) to platinum-based chemotherapy but succumbing resistance within 6 months advanced stages. associates with the transdifferentiation of residual tumour into non-neuroendocrine state, process...
Abstract. Water resources are an important component of the earth's system, and frequent occurrence floods droughts in context current climate change makes rapid accurate monitoring water particularly important. The optical index (OWI) is a commonly used method for extracting areas on basis remote sensing images, often with high level automation. However, selecting right OWI challenging due to variety types. To quantitatively evaluate differences mapping potential different OWIs surface...
Bone defects are common consequences of bone trauma. The application biomaterials as tissue scaffolds combined with oxygenating agents, regeneration promoters, is an interesting strategy to improve repair. present study aimed investigate the potential a temperature-sensitive hydrogel containing 1-bromoheptafluorooctane in repairing rabbit and its possible mechanism action. were surgically created femoral condylar New Zealand White rabbits. animals divided into three groups: A) treated oxygen...