A5032218168- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Malaria Research and Control
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
2022-2025
University of Liverpool
2022-2024
University of Malawi
2019-2022
BackgroundThe effect of childhood pneumococcal conjugate vaccine implementation in Malawi is threatened by absence herd effect. There persistent vaccine-type carriage both vaccinated children and the wider community. We aimed to use a human infection study measure 13-valent (PCV13) efficacy against carriage.MethodsWe did double-blind, parallel-arm, randomised controlled trial investigating PCV13 or placebo experimental Streptococcus pneumoniae serotype 6B (strain BHN418) among healthy adults...
Abstract Background Reducing the burden of malaria highly depends on access to prompt and effective diagnosis treatment. The aim this study was identify challenges affecting uncomplicated case management in children below 10 years old rural primary health care facilities Malawi. Methods A cross sectional facility survey conducted six Chikhwawa district, Officers-in-charge were interviewed availability staff, supplies drugs. All consecutive presenting at with fever or suspected malaria, aged...
Abstract Background In Malawi, the national 13-valent pneumococcal conjugate vaccine (PCV13) demonstrated less herd immunity than in United States, likely due to higher natural carriage rates. We assessed PCV13 efficacy against experimental healthy Malawian adults. explored how (pneumococcal of any serotype apart from 6B) influenced rates and efficacy. Methods Healthy adults aged 18 40 years were randomly assigned (n = 98) or saline 106), followed by intranasal SPN 6B inoculation at 20 000...
<ns4:p>Background <ns4:italic>Streptococcus pneumoniae</ns4:italic> is a major cause of morbidity and mortality from respiratory tract infections, pneumonia, meningitis, sepsis. Nasopharyngeal carriage pneumococcus prerequisite for pneumococcal disease transmission. Since the global introduction conjugated vaccines, rates have declined many vaccine type serotypes but serotype 3 (SPN3) continues to significant disease. The Experimental Human Pneumococcal Challenge (EHPC) model unique method...
Background: The impact of childhood pneumococcal conjugate vaccine implementation in Malawi is threatened by lack herd immunity. There persistent vaccine-type carriage both vaccinated children and the wider community. We used measured efficacy against experimental a human infection study.Methods: 278 healthy adults were recruited to double-blind randomised controlled trial 13-valent placebo. Four weeks after vaccine/placebo, participants challenged with 20,000 (n=42), 80,000 (n=81) or...