A5044650915- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Microscopic Colitis
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Gastrointestinal motility and disorders
University of Michigan
2021-2022
Michigan State University
2022
Microbiomes provide critical functions that support animals, plants, and ecosystems. High-throughput sequencing (HTS) has become an essential tool for the cultivation-independent study of microbiomes found in diverse environments, but requires effective meaningful controls. One such control is a mock microbial community, which used as positive nucleic acid extraction, marker gene amplification, sequencing. While community standards can be purchased, they costly often include only medically...
Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the microbiota. However, nonantibiotic medications such as ubiquitous osmotic laxative polyethylene glycol 3350 (PEG 3350) also alter Clinicians hypothesize that PEG helps clear C. difficile. But whether impacts CDI susceptibility and clearance is unclear. To examine how susceptibility, we treated C57BL/6 mice with 5-day 1-day doses 15% in drinking water then challenged 630. We used...
Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is only used once CDI becomes resistant to antibiotics or has recurred multiple times. We sought investigate whether a fecal community transplant (FCT) pretreatment could be prevent altogether. treated male C57BL/6 mice either clindamycin, cefoperazone, streptomycin and then inoculated them the microbial from untreated before challenge...
Abstract Fecal communities transplanted into individuals can eliminate recurrent Clostridioides difficile infection (CDI) with high efficacy. However, this treatment is only used once CDI becomes resistant to antibiotics or has recurred multiple times. We sought investigate whether a fecal community transplant (FCT) pre-treatment could be prevent altogether. treated male C57BL/6 mice either clindamycin, cefoperazone, streptomycin, and then inoculated them the microbial from untreated before...
Abstract Antibiotics are a major risk factor for Clostridioides difficile infections (CDIs) because of their impact on the microbiota. However, non-antibiotic medications such as ubiquitous osmotic laxative polyethylene glycol (PEG) 3350 also alter Clinicians hypothesize that PEG helps clear C. . But whether impacts CDI susceptibility and clearance is unclear. To examine how susceptibility, we treated C57Bl/6 mice with 5-day 1-day doses 15% in drinking water then challenged 630. We used...