A5052488928- Nitric Oxide and Endothelin Effects
- Pulmonary Hypertension Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Oral and Maxillofacial Pathology
- Hydrogen's biological and therapeutic effects
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Infective Endocarditis Diagnosis and Management
- Autoimmune Bullous Skin Diseases
- Alcoholism and Thiamine Deficiency
- Biochemical Acid Research Studies
- Respiratory Support and Mechanisms
- Circadian rhythm and melatonin
- Esophageal and GI Pathology
- Streptococcal Infections and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bone Tumor Diagnosis and Treatments
- Cardiovascular Health and Disease Prevention
- Sarcoma Diagnosis and Treatment
- Medical Research and Treatments
- Infectious Diseases and Mycology
- Eosinophilic Disorders and Syndromes
- Phonocardiography and Auscultation Techniques
Tokyo Dental College
2025
University of Tsukuba
2023-2024
Juntendo University
1994-1996
University of Colorado Health
1990-1994
To investigate the role of endothelin-1 (ET-1) in pathogenesis hypoxic pulmonary hypertension, we studied effects a recently described endothelin-receptor antagonist (ETA), BQ123, on development this process. Intraperitoneal osmotic pumps were placed into 8-wk-old Sprague-Dawley rats that received either saline or BQ123 (0.15 mg/h). The maintained room air normoxia hypobaric chamber (380 Torr) for 2 wk to induce hypertension. There no hemodynamic differences between normoxic treated with...
We have previously reported that the isolated rat branch pulmonary artery (PA) contracts when made hypoxic and contraction is dependent in large part on presence of a functioning endothelium. This study tested if was caused by reduced endothelium-derived relaxing factor (EDRF) activity. To do so we chemical inhibitors EDRF mimicked effect hypoxia, PA guanosine 3',5'-cyclic monophosphate (cGMP) fell during contraction, stimulation smooth muscle cGMP attenuated contraction. found hemoglobin...
Recent studies indicate that the endothelium of isolated rat pulmonary arteries releases two different factors, endothelium-derived relaxing factor (EDRF) and hyperpolarizing (EDHF), which participate in histamine- acetylcholine-induced relaxation. There is evidence for EDRF vasoreactivity perfused lungs, but a role EDHF, hyperpolarizes vascular smooth muscle by activating membrane K+ channels, has not been reported. We used inhibitors EDRF, 20 microM hemoglobin, 200...
To evaluate the role of endothelin (ET) receptors in ET-1-induced pulmonary vasoreactivity, we studied effects ET-receptor agonists and antagonists isolated perfused rat lungs. ET-1 (1-10 nM) caused concentration-dependent vasoconstriction gross edema at a concentration 10 nM. The combination selective ETA antagonist BQ-123 ETB BQ-788 inhibited more effectively than alone, whereas alone enhanced constriction. hydrostatic was prevented by but not either or alone. After addition 125 ng...
Endothelin 1 (ET-1), a peptide produced by endothelial cells, causes transient dilation of some systemic vascular beds. To test whether low concentrations ET-1 could also dilate the pulmonary bed, we examined its effects in isolated blood- and salt solution-perfused rat lungs conscious catheterized rats. In blood-perfused undergoing hypoxic (3% O2) vasoconstriction, repeated additions 0.5 nM to perfusate elicited partial vasodilations. The higher concentration 5 caused larger vasodilation...
To test whether endothelium-derived relaxing factor (EDRF) plays a role in regulating the hypertensive pulmonary vascular bed, we compared effects of inhibitor EDRF production, N omega-nitro-L-arginine (L-NNA), on resting tone lungs and conduit arteries isolated from control chronically hypoxic rats. In contrast to no effect normoxic salt solution-perfused normotensive lungs, 100 microM L-NNA caused marked, L-arginine-sensitive, precapillary vasoconstriction unstimulated lungs. Bioassay lung...
Objective This study aimed to compare the efficacy of dexamethasone alone and dexamethasone-ondansetron combined for preventing postoperative nausea vomiting (PONV) in patients undergoing orthognathic surgery. Methods Patients scheduled undergo mandibular surgery who were 18 50 years age American Society Anesthesiologists physical status I or II enrolled. Dexamethasone 6.6 mg was administered after intubation, followed by either ondansetron 4 (group DO) saline placebo D) 15 minutes before...
A rebound phenomenon (severe arterial desaturation and pulmonary vasoconstriction) has been observed in some patients with hypertension after sudden discontinuation of nitric oxide (NO) inhalation therapy. The mechanism responsible for this is unknown. It recently reported that NO synthase (NOS) can be inhibited by as a negative feedback mechanism. We therefore hypothesized might attributable to reduced endogenous production due inhibition endothelial NOS (eNOS) activity inhaled NO. To test...
17β-estradiol (E2) regulates various forms of social behavior through the activation two types estrogen receptors, ERα and ERβ. The lateral septum (LS) is thought to be one potential target sites E2, but role played by ERβ in this brain area remains largely unknown. In present study, we first analyzed distribution with double fluorescent immunohistochemistry a transgenic mouse line which red protein (RFP) signal has been reliable marker expression. overall number ERβ-RFP-expressing cells was...
The sexual receptivity of female mice, shown as lordosis response, is mainly regulated by estradiol action on estrogen receptor alpha (ERα) and beta (ERβ), depending the day estrous cycle. Previous studies revealed that ERα in ventromedial nucleus hypothalamus (VMH) plays an essential role induction estrus (Day 1). However, mechanisms transition to non-receptive states after 2) are not completely understood. In present study, we investigated possible ERβ, which highly expressed dorsal raphe...
A case of rheumatic heart disease with dominant mitral stenosis is presented in which a peculiar musical mid-diastolic and presystolic murmur was heard recorded phonocardiographically.The characterized by the tonal qualities simulating vibrations produced stringed instrument, such as harp. The varied intensity from cycle to also position, maximal presystole. At necropsy, an abnormal anatomic chorda tendinea, pathologically thickened rheumatism, found be strung across orifice.The sounds...