A5004386025- RNA Research and Splicing
- Advanced Photocatalysis Techniques
- Genomics and Chromatin Dynamics
- Electrocatalysts for Energy Conversion
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Advanced battery technologies research
- RNA Interference and Gene Delivery
- Copper-based nanomaterials and applications
- interferon and immune responses
- Circular RNAs in diseases
- Plant Molecular Biology Research
- Nanomaterials for catalytic reactions
- Cancer-related gene regulation
- Covalent Organic Framework Applications
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- 2D Materials and Applications
- Iron oxide chemistry and applications
- Cancer, Hypoxia, and Metabolism
- Adenosine and Purinergic Signaling
- Eating Disorders and Behaviors
- Proteoglycans and glycosaminoglycans research
- Kruppel-like factors research
Northeast Forestry University
2017-2024
Korea University
2022-2023
University of Leeds
2019-2022
Wuhan Polytechnic University
2022
Changsha Central Hospital
2014
JiangSu Armed Police General Hospital
2009
Abstract G-quadruplexes (G4s) can recruit transcription factors to activate gene expression, but detailed mechanisms remain enigmatic. Here, we demonstrate that G4s in the CCND1 promoter propel motility MAZ phase-separated condensates and subsequently transcription. Zinc finger (ZF) 2 of is a responsible for G4 binding, while ZF3-5, not highly disordered region, critical condensation. nuclear puncta overlaps with signals various coactivators including BRD4, MED1, CDK9 active RNA polymerase...
Abstract As an oncogenic transcription factor, Yin Yang 1 (YY1) regulates enhancer and promoter connection. However, gaps still exist in understanding how YY1 coordinates coactivators chromatin elements to assemble enhancers super-enhancers. Here, we demonstrate that a histidine cluster YY1’s transactivation domain is essential for its formation of phase separation condensates, which can be extended additional proteins. The also required YY1-promoted cell proliferation, migration,...
CoO/CoP heterostructure hollow-nanoneedles with interfacially strong P–Co–O tetrahedral coupling interaction effectively improve the activity and kinetics for overall water splitting.
Under visible-light irradiation, ternary LaFeO 3 @NGr–Pt NPs Z-scheme delivered a PHE performance (3.52 μmol mg cat −1 h ) superior to binary @NGr (1.86 ), NGr–Pt (0.88 and NGr (0.34 ).
Enhancer of zeste homolog 2 (EZH2) is a methyltransferase to mediate lysine 27 trimethylation in histone H3 (i.e., H3K27me3) and repress gene expression. In solid tumors, EZH2 promotes oncogenesis considered therapeutic target. As transcription factor, Yin Yang 1 (YY1) recruits through its oncoprotein binding (OPB) domain establish repression. this study, we mapped the YY1 protein (YPB) on region amino acids. Both YPB OPB synthetic peptides could disrupt YY1EZH2 interaction, markedly reduce...
In this study, different morphologies of molybdenum disulfide (MoS2), including MoS2 nanoparticle (NP), nanoflower (NF), nanosphere (NS), nanohollow (NH), and MoS2/MoO2 composite, are successfully synthesized via a facile-route hydrothermal process employing solutions. The structure chemical bonding the investigated X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscopy (SEM), photoelectron spectroscopy (XPS). Thereafter, materials applied to hydrogen evolution reaction...
Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death worldwide, but underlying molecular mechanisms remain largely unclear. The transcription factor (TF) specificity protein 1 (SP1) plays a crucial role in development various cancers, including LUAD. Recent studies have indicated that master TFs may form phase-separated macromolecular condensates to promote super-enhancer (SE) assembly and oncogene expression. In this study, we demonstrated SP1 undergoes phase separation...
G-quadruplexes (G4s) regulate DNA replication and gene transcription, are enriched in promoters without fully appreciated functional relevance. Here we show high selection pressure on putative G4 (pG4) forming sequences through investigating genetic genomic data. Analyses of 76,156 whole-genome reveal that G-tracts connecting loops promoter pG4s display lower or higher allele frequencies, respectively, than pG4-flanking regions, central guanines (Gs) other Gs. Additionally, pG4-promoters...
High concentration of extracellular ADP has been reported to induce cell apoptosis, but the molecular mechanisms remain not fully elucidated. In this study, we found by serendipity that treatment human umbilical vein endothelial cells (HUVEC) and aortic (HAEC) down-regulated protein level nucleolin in a dose- time-dependent manner. did decrease transcript nucloelin, suggesting might degradation. HUVEC HAEC expressed receptor P2Y13 receptor, express P2Y1 or P2Y12 receptors. However, P2Y1, 12,...
Ce SAs on porous NGr (1Ce/NGr) show potential for HER with low onset overpotential and high stability. The modified environment of active sites facilitates water adsorption dissociation, liberating hydrogen.
Yin Yang 1 (YY1) plays an oncogenic role through regulating the expression of various cancer-related genes and activating key oncoproteins. Previous research reported that YY1 protein formed dimers or oligomers without definite biological implications. In this study, we first demonstrated oncoprotein binding (OPB) zinc finger (ZF) domains as regions involved in its intermolecular interactions. ZFs are well-known for dimerization, so focused on OPB domain. After mutating three hydrophobic...